Engineering living systems on chips: from cells to human on chips
| العنوان: | Engineering living systems on chips: from cells to human on chips |
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| المؤلفون: | Kyle Justus, YongTae Kim, Philip R. LeDuc, Yoshitaka J. Sei |
| المصدر: | Microfluidics and Nanofluidics. 16:907-920 |
| بيانات النشر: | Springer Science and Business Media LLC, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Tissue engineering, Computer science, Microfluidics, Materials Chemistry, Systems engineering, Nanotechnology, Condensed Matter Physics, Organ-on-a-chip, Regenerative medicine, Electronic, Optical and Magnetic Materials, Variety (cybernetics), Living systems |
| الوصف: | Engineering living systems on chips is an emerging direction with a goal to mimic physiologically accurate biological functions that can be applied to a diversity of applications, such as reliable in vitro drug-screening systems for reducing the need for animal testing. Taking advantages of creative platforms from electromechanical systems technology and from advanced biomaterials to mimic 3D extracellular matrix, these approaches to recapitulating organ-level structures and functions may bring unprecedented benefits to clinical translation of nanomedicines in the pharmaceutical and biomedical industries and to advanced tissue engineering for regenerative medicine. In this review, we discuss recent progress on the engineering of living systems on chips and highlight advanced technologies that integrate a variety of physiological cues including mechanical, chemical, and electrical signals with precise spatiotemporal controls. We also discuss current challenges and future directions of these approaches, analyzing the benefits of continued research in this field. |
| تدمد: | 1613-4990 1613-4982 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::5836698fc5d51fd0edd8bec3c79cf068 https://doi.org/10.1007/s10404-014-1341-y |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi...........5836698fc5d51fd0edd8bec3c79cf068 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 16134990 16134982 |
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