PSA-stratified detection rates for [68Ga]THP-PSMA, a novel probe for rapid kit-based 68Ga-labeling and PET imaging, in patients with biochemical recurrence after primary therapy for prostate cancer
| العنوان: | PSA-stratified detection rates for [68Ga]THP-PSMA, a novel probe for rapid kit-based 68Ga-labeling and PET imaging, in patients with biochemical recurrence after primary therapy for prostate cancer |
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| المؤلفون: | Sebastian Schmuck, Frank M. Bengel, Christoph A. J. von Klot, Christoph Henkenberens, Hans Christiansen, Cathleen Juhl, Thorsten Derlin, Johanna Zörgiebel, Sophie M. Schneefeld, Katja Hueper, Tobias L. Ross, James T. Thackeray, Almut Walte |
| المصدر: | European Journal of Nuclear Medicine and Molecular Imaging. 45:913-922 |
| بيانات النشر: | Springer Science and Business Media LLC, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Biochemical recurrence, PET-CT, medicine.medical_specialty, medicine.diagnostic_test, Prostatectomy, business.industry, medicine.medical_treatment, Urology, General Medicine, urologic and male genital diseases, medicine.disease, 030218 nuclear medicine & medical imaging, Androgen deprivation therapy, 03 medical and health sciences, Prostate-specific antigen, Prostate cancer, 0302 clinical medicine, Positron emission tomography, 030220 oncology & carcinogenesis, medicine, Radiology, Nuclear Medicine and imaging, Prospective cohort study, business |
| الوصف: | [68Ga]Tris(hydroxypyridinone)(THP)-PSMA is a novel radiopharmaceutical for one-step kit-based radiolabelling, based on direct chelation of 68Ga3+ at low concentration, room temperature and over a wide pH range, using direct elution from a 68Ge/68Ga-generator. We evaluated the clinical detection rates of [68Ga]THP-PSMA PET/CT in patients with biochemically recurrent prostate cancer after prostatectomy. Consecutive patients (n=99) referred for evaluation of biochemical relapse of prostate cancer by [68Ga]THP-PSMA PET/CT were analyzed retrospectively. Patients underwent a standard whole-body PET/CT (1 h p.i.), followed by delayed (3 h p.i.) imaging of the abdomen. PSA-stratified cohorts of positive PET/CT results, standardized uptake values (SUVs) and target-to-background ratios (TBRs) were analyzed, and compared between standard and delayed imaging. At least one lesion suggestive of recurrent or metastatic prostate cancer was identified on PET images in 52 patients (52.5%). Detection rates of [68Ga]THP-PSMA PET/CT increased with increasing PSA level: 94.1% for a PSA value of ≥10 ng/mL, 77.3% for a PSA value of 2 to 0.2 to |
| تدمد: | 1619-7089 1619-7070 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::58bd3921fdd85ee85afeed073b6dad00 https://doi.org/10.1007/s00259-017-3924-9 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi...........58bd3921fdd85ee85afeed073b6dad00 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 16197089 16197070 |
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