N-glycosylation bidirectionally extends the boundaries of thymocyte positive selection by decoupling Lck from Ca2+ signaling
| العنوان: | N-glycosylation bidirectionally extends the boundaries of thymocyte positive selection by decoupling Lck from Ca2+ signaling |
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| المؤلفون: | David Chen, Araz Arakelyan, Haik Mkhikian, Michael A. Demetriou, Ani Grigorian, Raymond W. Zhou, Amanda Hong |
| المصدر: | Nature Immunology. 15:1038-1045 |
| بيانات النشر: | Springer Science and Business Media LLC, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Chemistry, Positive selection, Immunology, T-cell receptor, chemical and pharmacologic phenomena, Cell biology, Thymocyte, N-linked glycosylation, mental disorders, Immunology and Allergy, psychological phenomena and processes, Ca2 signaling, CD8, Decoupling (electronics) |
| الوصف: | Thymocytes are positively selected upon recognition of self peptide–MHC complexes. Demetriou and colleagues show that N-glycosylation of TCR and coreceptor molecules increases the number of CD4+CD8+ thymocytes that are positively selected. |
| تدمد: | 1529-2916 1529-2908 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::58e51daa4a401a60e3bee4805f4a39cc https://doi.org/10.1038/ni.3007 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi...........58e51daa4a401a60e3bee4805f4a39cc |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15292916 15292908 |
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