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The synthesis and biological activity of tetrahydroquinoline angiotensin II antagonists containing a substituted biphenyltetrazole group

التفاصيل البيبلوغرافية
العنوان:	The synthesis and biological activity of tetrahydroquinoline angiotensin II antagonists containing a substituted biphenyltetrazole group
المؤلفون:	David Anthony Roberts, Andrew Peter Thomas, Douglas A. Thomason
المصدر:	Bioorganic & Medicinal Chemistry Letters. 4:2615-2620
بيانات النشر:	Elsevier BV, 1994.
سنة النشر:	1994
مصطلحات موضوعية:	Chemistry, Stereochemistry, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, Angiotensin ii antagonist, Biological activity, Biochemistry, Angiotensin II, In vitro, Pressor response, Drug Discovery, Molecular Medicine, Molecular Biology
الوصف:	The synthesis of analogues of tetrahydroquinoline angiotensin II antagonist, ZENECA ZD6888, bearing substituents on the biphenyl ring system is reported. Several of these compounds show comparable or superior activity to ZD6888 in an in vitro beinding assay and in inhibition of the AII-induced pressor response in normotensive rats.
تدمد:	0960-894X
URL الوصول:	https://explore.openaire.eu/search/publication?articleId=doi_________::58e911db5f14c3a0a4b1b40741fd4719 https://doi.org/10.1016/s0960-894x(01)80295-x
حقوق:	CLOSED
رقم الأكسشن:	edsair.doi...........58e911db5f14c3a0a4b1b40741fd4719
قاعدة البيانات:	OpenAIRE

الوصف
تدمد:	0960894X