Strukturrevision des 4-Hydroxyaloin: 10-Hydroxyaloine A und B als Haupt-In vitro-Oxidationsprodukte der diastereomeren Aloine1
| العنوان: | Strukturrevision des 4-Hydroxyaloin: 10-Hydroxyaloine A und B als Haupt-In vitro-Oxidationsprodukte der diastereomeren Aloine1 |
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| المؤلفون: | HW Rauwald, Karsten Lohse |
| المصدر: | Planta Medica. 58:259-262 |
| بيانات النشر: | Georg Thieme Verlag KG, 1992. |
| سنة النشر: | 1992 |
| مصطلحات موضوعية: | Pharmacology, Organic Chemistry, Diastereomer, Pharmaceutical Science, Aloin, Anthrone, In vitro, Analytical Chemistry, Ammonia, chemistry.chemical_compound, Complementary and alternative medicine, chemistry, Drug Discovery, Molecular Medicine, Molecule, Organic chemistry, Anthranoid, Derivative (chemistry) |
| الوصف: | A reinvestigation of the anthrone derivative 4-hydroxyaloin as main product of the mild IN VITRO-oxidation of aloin has led to the revision of the proposed structure as the aloin-analogous oxanthrone derivative, the new 10-hydroxyaloin, which was prepared from aloin by an improved procedure in ammonia at pH 9. 10-Hydroxyaloin was separated into its C10-diastereomers A and B by analytical and preparative chromatographic methods. Their structures were elucidated by spectroscopic methods (FAB-MS; (1)H/ (13)C-NMR; CD), which show that 10-hydroxyaloin A is the 10 R,1' R compound and that 10-hydroxyaloin B has the 10 S,1' R-configuration. |
| تدمد: | 1439-0221 0032-0943 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::5962cf05dceadcfc422942a1bc3e90fd https://doi.org/10.1055/s-2006-961448 |
| رقم الأكسشن: | edsair.doi...........5962cf05dceadcfc422942a1bc3e90fd |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14390221 00320943 |
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