التفاصيل البيبلوغرافية
| العنوان: |
Differential Hematopoietic Activity in White Adipose Tissue Depending on its Localization |
| المؤلفون: |
Emmanuelle Arnaud, Béatrice Cousin, Coralie Sengenès, Patrick Laharrague, Louis Casteilla, Elodie Luche |
| المصدر: |
Journal of Cellular Physiology. 230:3076-3083 |
| بيانات النشر: |
Wiley, 2015. |
| سنة النشر: |
2015 |
| مصطلحات موضوعية: |
Stromal cell, Physiology, Clinical Biochemistry, Cell, nutritional and metabolic diseases, Adipose tissue, Cell Biology, White adipose tissue, Biology, Fat pad, Cell biology, Haematopoiesis, medicine.anatomical_structure, Immune system, Immunology, medicine, Progenitor cell |
| الوصف: |
White adipose tissue (WAT) can be found in different locations in the body, and these different adipose deposits exhibit specific physiopathological importance according to the subcutaneous or abdominal locations. We have shown previously the presence of functional hematopoietic stem/progenitor cells (HSPC) in subcutaneous adipose tissue (SCAT). These cells exhibit a specific hematopoietic activity that contributes to the renewal of the immune cell compartment within this adipose deposit. In this study, we investigated whether HSPC can be found in visceral adipose tissue (VAT) and whether a putative difference in in situ hematopoiesis may be related to anatomical location and to site-specific immune cell content in VAT compared to SCAT. Therein, we identified for the first time the presence of HSPC in VAT. Using both in vitro assays and in vivo competitive repopulation experiments with sorted HSPC from VAT or SCAT, we showed that the hematopoietic activity of HSPC was lower in VAT, compared to SCAT. In addition, this altered hematopoietic activity of HSPC in VAT was due to their microenvironment, and may be related to a specific combination of secreted factors and extracellular matrix molecules expressed by adipose derived stromal cells. Our results indicate that WAT specific hematopoietic activity may be generalized to all adipose deposits, although with specificity according to the fat pad location. Considering the abundance of WAT in the body, this emphasizes the potential importance of this hematopoietic activity in physiopathological situations. J. Cell. Physiol. 230: 3076–3083, 2015. © 2015 Wiley Periodicals, Inc. |
| تدمد: |
0021-9541 |
| URL الوصول: |
https://explore.openaire.eu/search/publication?articleId=doi_________::5a11c0253defeeaca1b773108a2dca75
https://doi.org/10.1002/jcp.25045 |
| حقوق: |
CLOSED |
| رقم الأكسشن: |
edsair.doi...........5a11c0253defeeaca1b773108a2dca75 |
| قاعدة البيانات: |
OpenAIRE |
