Synthesis of [1,2-3H]ethylamine hydrochloride and [3H]-labeled apadenoson for a human ADME study
| العنوان: | Synthesis of [1,2-3H]ethylamine hydrochloride and [3H]-labeled apadenoson for a human ADME study |
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| المؤلفون: | Paul D. Crane, James F. Castner, Edward H. Cheesman, Yang Hong, Yuan Tian, Balu Balasubramanian, Sharon Gong, Samuel J. Bonacorsi, Zhiqin Zhang, Donglu Zhang, W. Griffith Humphreys |
| المصدر: | Journal of Labelled Compounds and Radiopharmaceuticals. 51:113-117 |
| بيانات النشر: | Wiley, 2008. |
| سنة النشر: | 2008 |
| مصطلحات موضوعية: | Agonist, Chromatography, medicine.drug_class, Chemistry, Organic Chemistry, ADME Study, Carboxamide, Uronic acid, Biochemistry, Chemical synthesis, Analytical Chemistry, chemistry.chemical_compound, Yield (chemistry), Drug Discovery, medicine, Organic chemistry, Radiology, Nuclear Medicine and imaging, Amine gas treating, Tritium, Spectroscopy |
| الوصف: | Tritium-labeled [1,2-3H]ethylamine hydrochloride was prepared through a multiple-step sequence in high radioactive specificity. The labeled amine was isolated in high purity following cartridge filtration and used subsequently in the synthesis of [N-ethyl-1,2-3H]apadenoson, an adenosine A2a receptor agonist. The overall yield for this transformation was 56% and the radiochemical purity of the final product was greater than 99%. Copyright © 2008 John Wiley & Sons, Ltd. |
| تدمد: | 1099-1344 0362-4803 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::5a7504f8f87836eb3761d16af60d21f7 https://doi.org/10.1002/jlcr.1495 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi...........5a7504f8f87836eb3761d16af60d21f7 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10991344 03624803 |
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