KIFC1 promotes the proliferation of hepatocellular carcinoma in�vitro and in�vivo
| العنوان: | KIFC1 promotes the proliferation of hepatocellular carcinoma in�vitro and in�vivo |
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| المؤلفون: | Xing Wang, Jian Li, Xing‑Yue Li, Dian‑Peng Zhao, Meng Wang |
| المصدر: | Oncology Letters. |
| بيانات النشر: | Spandidos Publications, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | 0301 basic medicine, Cancer Research, Oncogene, KIF15, business.industry, medicine.medical_treatment, Cancer, Cell cycle, medicine.disease, Molecular medicine, digestive system diseases, Targeted therapy, Metastasis, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Oncology, 030220 oncology & carcinogenesis, Hepatocellular carcinoma, medicine, Cancer research, business, neoplasms |
| الوصف: | Hepatocellular carcinoma (HCC) is a common type of malignant tumor worldwide with a high mortality rate. In the past 20 years, the morbidity rate of HCC has increased. Progress has been made in the clinical diagnosis and therapy for HCC. However, due to the high heterogeneity and metastasis targeted therapy for HCC exhibits great promise, and novel therapeutic targets for HCC are urgently required. Kinesin family member C1 (KIFC1) is a member of the kinesin superfamily of proteins. Previous studies have indicated a potential association between KIFC1 and cancer progression. However, the potential role of KIFC1 in the development of HCC remains unclear. The present study aimed to explore the function of KIFC1 in HCC. Immunohistochemical (IHC) assays were performed to explore the KIF15 expression levels in 74 samples of HCC and corresponding non-tumor tissues. The potential association between KIF15 expression levels and clinical features was analyzed, and the effects of KIF15 on cell proliferation of HCC were detected by colony formation and MTT assays. In addition, the proliferation-related proteins Ki67 and PCNA were detected by western blotting. The possible effects of KIF15 on tumor growth were measured in mice. The results demonstrated that a high expression level of KIFC1 was associated with poor prognosis of HCC. Further results indicated that KIFC1 promoted cell proliferation of HCC in vitro. In addition, knockdown of KIFC1 suppressed tumor formation and growth in mice. Therefore, these results provide a potential therapeutic target for the treatment of HCC. |
| تدمد: | 1792-1082 1792-1074 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::5a9ae0ae958849aced1692767ee13270 https://doi.org/10.3892/ol.2019.10985 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi...........5a9ae0ae958849aced1692767ee13270 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17921082 17921074 |
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