In vitro evaluation of combination effects of doxorubicin with methylxanthine fractions isolated from Bancha and Pu-erh teas against breast cancer cells
| العنوان: | In vitro evaluation of combination effects of doxorubicin with methylxanthine fractions isolated from Bancha and Pu-erh teas against breast cancer cells |
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| المؤلفون: | Kaloyan Georgiev, Ivan A. Iliev, Iliya J. Slavov |
| المصدر: | International Journal of Basic & Clinical Pharmacology. 8:2167 |
| بيانات النشر: | Medip Academy, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | business.industry, Cancer research, Medicine, Doxorubicin, Breast cancer cells, business, In vitro, medicine.drug |
| الوصف: | Background: In the present study we investigated the combination effects of anthracycline antibiotic, doxorubicin, with methylxanthine fractions isolated from Bancha and Pu-erh tea leaves, against MCF-7 and MDA-MB-231 breast cancer cell lines.Methods: Neutral red uptake assay was used for assessment of cytotoxicity effects and fractional effect analysis and combination index for evaluation of the combination effects.Results: Doxorubicin was used in varying concentrations by a double dilution method, whereas the methylxanthine fractions were in fixed concentrations – 100, 200, 400 or 600 μg/ml. Results have shown that methylxanthine fraction isolated from Bancha has synergic effects with doxorubicin, while methylxanthines from Pu-erh displayed antagonistic effects.Conclusions: Тhe obtained results lead us to suspect, that even minor differences in the composition of natural products can lead to significant differences in the biological activity of the product. |
| تدمد: | 2279-0780 2319-2003 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::5c57d4c70f09902ba264aa69e05e68fc https://doi.org/10.18203/2319-2003.ijbcp20194254 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi...........5c57d4c70f09902ba264aa69e05e68fc |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 22790780 23192003 |
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