Serum vitamin D receptor levels in gestational diabetes mellitus
| العنوان: | Serum vitamin D receptor levels in gestational diabetes mellitus |
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| المؤلفون: | Necat Yilmaz, Hamit Yasar Ellidag, Seçkin Özgür Tekeli, Feyza Tekeli, Onur Erol, Esin Eren |
| المصدر: | LaboratoriumsMedizin. 42:149-154 |
| بيانات النشر: | Walter de Gruyter GmbH, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Serum vitamin, medicine.medical_specialty, business.industry, Insulin, medicine.medical_treatment, Biochemistry (medical), Clinical Biochemistry, 030209 endocrinology & metabolism, medicine.disease, Calcitriol receptor, Gestational diabetes, 03 medical and health sciences, Medical Laboratory Technology, 0302 clinical medicine, Endocrinology, Internal medicine, medicine, Vitamin D and neurology, 030212 general & internal medicine, business, Receptor |
| الوصف: | BackgroundVitamin D affects glucose metabolism by increasing insulin secretion and insulin receptor expression. Also, it exerts these effects by binding to its primary receptor, the vitamin D receptor (VDR). In this preliminary study, we aimed to examine serum 25-(OH) vitamin D3and serum VDR levels in gestational diabetes mellitus (GDM) patients.MethodsBlood samples were obtained during 24–28 weeks of pregnancy from patients with GDM (n=30) and age, body mass index (BMI), and gestational age-matched control subjects (n=33). Both groups were examined for changes in the levels of glucose, insulin, glycated hemoglobin (bA1c), 25-(OH) vitamin D3and VDR.ResultsThere were no significant differences in serum 25-(OH) vitamin D3and fasting insulin levels between the control and GDM groups (p=0.115, p=0.182). But serum VDR levels were significantly higher in the GDM group than in the control group (p=0.001).ConclusionsAlthough there was no significant difference between the two groups regarding 25-(OH) vitamin D3levels, it is notable that VDR levels were higher in GDM patients. To further define the role of vitamin D in the prophylaxis and treatment of GDM, it may be useful to conduct more extensive studies on VDR. |
| تدمد: | 1439-0477 0342-3026 2017-0149 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::5d0ad7edefb8e15e1ec0b4d5116357bc https://doi.org/10.1515/labmed-2017-0149 |
| رقم الأكسشن: | edsair.doi...........5d0ad7edefb8e15e1ec0b4d5116357bc |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14390477 03423026 20170149 |
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