Importance of the Detection Method for Thyroglobulin Antibodies for the Validity of Thyroglobulin Measurements in Sera from Patients with Graves Disease
| العنوان: | Importance of the Detection Method for Thyroglobulin Antibodies for the Validity of Thyroglobulin Measurements in Sera from Patients with Graves Disease |
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| المؤلفون: | Catherine Massart, D. Maugendre |
| المصدر: | Clinical Chemistry. 48:102-107 |
| بيانات النشر: | Oxford University Press (OUP), 2002. |
| سنة النشر: | 2002 |
| مصطلحات موضوعية: | medicine.medical_specialty, Validation study, biology, business.industry, medicine.medical_treatment, Graves' disease, Biochemistry (medical), Clinical Biochemistry, Cross reactions, medicine.disease, Endocrinology, Internal medicine, Immunopathology, medicine, biology.protein, Thyroglobulin, Antibody, business |
| الوصف: | Background: The use of recovery tests has been proposed to disclose interferences from anti-thyroglobulin antibodies (TgAbs) in thyroglobulin (Tg) assays. We studied the value of a recovery test in Tg measurement by a new commercial IRMA.Methods: Blood samples were collected from 153 patients with untreated Graves disease. Tg and TgAbs were measured by IRMA and RIA, respectively (Dynotest Tg-plus and Dynotest anti-Tgn; Brahms Diagnostica). The recoveries of added amounts of Tg were calculated for each serum.Results: TgAbs were detected in 72 of the 153 patients (47%). The recovery test results for the 81 TgAb-negative sera (median, 101%; range, 80–115%) were identical to the results for the 91 controls (median, 102%; range, 80–124%). By contrast, significantly lower recovery test results were observed for the 72 TgAb-positive sera (median, 79%; range, 60–103%; Z = −8.363; P Conclusions: Tg values were decreased in TgAb-positive sera even when the results of the recovery tests were normal. This test should not be used alone to determine the validity of a serum Tg measurement in Graves disease. |
| تدمد: | 1530-8561 0009-9147 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::5dc99752c0d96054fda8a049514048ed https://doi.org/10.1093/clinchem/48.1.102 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi...........5dc99752c0d96054fda8a049514048ed |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15308561 00099147 |
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