Driving HIV-specific vaccine responses in immune suppressed recipients (113.20)
| العنوان: | Driving HIV-specific vaccine responses in immune suppressed recipients (113.20) |
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| المؤلفون: | Lisa McEwen, Cac Bui, Yvonne Paterson, Donald Harn |
| المصدر: | The Journal of Immunology. 188:113.20-113.20 |
| بيانات النشر: | The American Association of Immunologists, 2012. |
| سنة النشر: | 2012 |
| مصطلحات موضوعية: | Immunology, Immunology and Allergy |
| الوصف: | Malaria, TB and HIV-1 remain tremendous disease burdens in much of the world’s population. Vaccines for these diseases are desperately needed. However, vaccine efficacy is likely to be compromised due to the systemic Th2 biasing and immune suppression caused by infection with parasitic helminthes. Our lab and others have shown that helminth infection suppresses Th1-type vaccine-specific responses. Although Sub-Saharan populations will benefit most from these vaccines, a large percentage of these populations live in helminth endemic regions. A goal of our research is to find vaccine vectors that drive significant HIV-specific immune responses in helminth infected recipients, despite the immune status of the individual. In the current study, we demonstrate that administration of an HIV vaccine (Listeria expressing HIV-1 gag protein) drives significant HIV-specific CTL and Th1 responses in mice chronically infected with the helminth parasite Schistosoma mansoni. These results suggest that Listeria vector vaccines likely will drive HIV-specific responses in helminth-infected human populations. Kinetic studies show that the HIV-vaccine-specific responses generated in schistosome infected mice are durable and capable of inducing CD4+ and CD8+ T cell memory. Further, Listeria vectors should be considered in the development of new generation HIV-1, malaria or TB vaccines to be administered to populations in sub-Saharan Africa where helminth infection is endemic. |
| تدمد: | 1550-6606 0022-1767 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::5deeb1c97b16efc2336d72f297207c4f https://doi.org/10.4049/jimmunol.188.supp.113.20 |
| رقم الأكسشن: | edsair.doi...........5deeb1c97b16efc2336d72f297207c4f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15506606 00221767 |
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