ChemInform Abstract: Synthesis and Evaluation of Novel 1,5-Benzodiazepines as Potent and Selective CCK-B Ligands. Effect of the Substitution of the N-5 Phenyl with Alkyl Groups
التفاصيل البيبلوغرافية
العنوان:
ChemInform Abstract: Synthesis and Evaluation of Novel 1,5-Benzodiazepines as Potent and Selective CCK-B Ligands. Effect of the Substitution of the N-5 Phenyl with Alkyl Groups
The synthesis and biological evaluation of both 3-ureido and 3-carbamate derivatives of 1,5-benzodiazepines bearing bulky alkyl substituents at N-1 and N-5 positions is reported. Their activity as CCK-B receptor antagonists is discussed and compared with the related N-5-phenyl derivatives.
