Counter-receptors on human basophils for endothelial cell adhesion molecules
| العنوان: | Counter-receptors on human basophils for endothelial cell adhesion molecules |
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| المؤلفون: | B S Bochner, S A Sterbinsky, M Briskin, S S Saini, D W MacGlashan |
| المصدر: | The Journal of Immunology. 157:844-850 |
| بيانات النشر: | The American Association of Immunologists, 1996. |
| سنة النشر: | 1996 |
| مصطلحات موضوعية: | Immunology, Immunology and Allergy |
| الوصف: | Ligands on human basophils for the endothelial adhesion molecules intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), mucosal addressin cell adhesion molecule-1 (MAdCAM-1), and E-selectin were investigated. Adhesion of basophils to endothelial cells was inhibited by mAb recognizing CD18, CD11a, and/or CD11b, with the pattern and magnitude of inhibition dependent upon the activation state of the basophils and endothelium. Adhesion to recombinant VCAM-1 was completely inhibited by mAb recognizing alpha 4 integrin and partially by mAb to the beta 1 or beta 7 subunit; surface expression of these integrins was also detected. Adhesion to recombinant MAdCAM-1 expressed on Chinese hamster ovary cells was completely inhibited by mAb recognizing alpha 4 and/or beta 7 integrins. Adhesion to recombinant E-selectin was completely inhibited by basophil pretreatment with neuraminidase and partially inhibited by endo-beta-galactosidase. By flow cytometry, bimodal patterns of expression of sialyl-Lewis X- and sialyl-dimeric-Lewis X were observed, and adherent cells tended to be sialyl-dimeric-Lewis X positive. Thus, basophils express beta 1, beta 2, and beta 7 integrins along with sialylated surface ligands that may interact with the endothelium during basophil recruitment responses. |
| تدمد: | 1550-6606 0022-1767 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::5f2fe3c27925802b45654a7947414516 https://doi.org/10.4049/jimmunol.157.2.844 |
| رقم الأكسشن: | edsair.doi...........5f2fe3c27925802b45654a7947414516 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15506606 00221767 |
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