Analysis of the CD4 coreceptor and activation-induced costimulatory molecules in antigen-mediated mature T lymphocyte death
| العنوان: | Analysis of the CD4 coreceptor and activation-induced costimulatory molecules in antigen-mediated mature T lymphocyte death |
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| المؤلفون: | S A Boehme, L Zheng, M J Lenardo |
| المصدر: | The Journal of Immunology. 155:1703-1712 |
| بيانات النشر: | The American Association of Immunologists, 1995. |
| سنة النشر: | 1995 |
| مصطلحات موضوعية: | Immunology, Immunology and Allergy |
| الوصف: | We have compared the signaling requirements for activation and lymphokine production in mature T lymphocytes to those required for TCR-driven programmed cell death (PCD). Both processes require TCR engagement and ligation of the CD4 coreceptor in the case of a T cell clone that recognizes Ag in the context of an MHC class II molecule. By contrast, stimulation through the CD28/B7 pathway does not appear to positively or negatively influence TCR-induced PCD, although it was required for IL-2 production in both resting and proliferating T cells. T cells that had been activated and induced to proliferate with IL-2 were found to express high levels of IL-2 mRNA upon TCR rechallenge, without a requirement for accessory cells. This was due to a strong up-regulation of the B7-1 molecule, but not the B7-2 molecule, on the T cell surface. These T cells that strongly costimulate each other are highly susceptible to TCR-induced death providing independent evidence that costimulatory signals are not protective. Thus, these results provide evidence that in mature T cells there exists a difference in the requirement for CD28 to achieve activation and IL-2 production compared with TCR-mediated PCD. |
| تدمد: | 1550-6606 0022-1767 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::5f73b61075087fe1bfed564cf6c23537 https://doi.org/10.4049/jimmunol.155.4.1703 |
| رقم الأكسشن: | edsair.doi...........5f73b61075087fe1bfed564cf6c23537 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15506606 00221767 |
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