Secretory MPP3 reinforce myeloid differentiation trajectory and amplify myeloid cell production
| العنوان: | Secretory MPP3 reinforce myeloid differentiation trajectory and amplify myeloid cell production |
|---|---|
| المؤلفون: | Yoon-A Kang, Hyojung Paik, Si Yi Zhang, Jonathan J. Chen, Oakley C. Olson, Carl A. Mitchell, Amelie Collins, James W. Swann, Matthew R. Warr, Rong Fan, Emmanuelle Passegué |
| المصدر: | Journal of Experimental Medicine. 220 |
| بيانات النشر: | Rockefeller University Press, 2023. |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | Immunology, Immunology and Allergy |
| الوصف: | Hematopoietic stem cells (HSC) and downstream lineage-biased multipotent progenitors (MPP) tailor blood production and control myelopoiesis on demand. Recent lineage tracing analyses revealed MPPs to be major functional contributors to steady-state hematopoiesis. However, we still lack a precise resolution of myeloid differentiation trajectories and cellular heterogeneity in the MPP compartment. Here, we found that myeloid-biased MPP3 are functionally and molecularly heterogeneous, with a distinct subset of myeloid-primed secretory cells with high endoplasmic reticulum (ER) volume and FcγR expression. We show that FcγR+/ERhigh MPP3 are a transitional population serving as a reservoir for rapid production of granulocyte/macrophage progenitors (GMP), which directly amplify myelopoiesis through inflammation-triggered secretion of cytokines in the local bone marrow (BM) microenvironment. Our results identify a novel regulatory function for a secretory MPP3 subset that controls myeloid differentiation through lineage-priming and cytokine production and acts as a self-reinforcing amplification compartment in inflammatory stress and disease conditions. |
| تدمد: | 1540-9538 0022-1007 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::5f7fb2e6ab476c9a7cd3c826ac8c6960 https://doi.org/10.1084/jem.20230088 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi...........5f7fb2e6ab476c9a7cd3c826ac8c6960 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15409538 00221007 |
|---|