Two Step Cost-Saving Process for Industrial Scale Production of 1-Amino-3,5-dimethyladamantane Hydrochloride (An Anti-Alzheimer’s Drug)
| العنوان: | Two Step Cost-Saving Process for Industrial Scale Production of 1-Amino-3,5-dimethyladamantane Hydrochloride (An Anti-Alzheimer’s Drug) |
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| المؤلفون: | Thi Hong Tham Nguyen, Viet Duc Le, Sy Thinh Ngo, Thi Hong Thanh Nguyen, Dinh Chau Phan, Binh Duong Vu |
| المصدر: | Asian Journal of Chemistry. 34:251-255 |
| بيانات النشر: | Asian Journal of Chemistry, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | General Chemistry |
| الوصف: | This work presents a predominant cost-saving process for the industrial scale synthesis of memantine hydrochloride (1) from 1,3-dimethyladamantane (2) by a two-step method in which both steps were carried out in one-pot. The conversion of 2 to N-(3,5-dimethyladamantane-1-yl)acetylamide (3) was synthesized first in mixture of sulfuric acid 96-98% and nitric acid 64-65% at 25 ºC for 2.5 h and then in acetonitrile at 40 ºC for 3.5 h as a key step. The yield of this process reached to 98%. Next, the deacetylation of 3 with potasium hydroxide in mixture of water-ethylene glycol at 140 ºC for 15 h to get memantine base which was then converted into memantine hydrochloride (1) by aq. HCl 14% (yield of 93%). Overall yield of this synthetic route was 91.65%. The advantages of this process is saving time, solvents, reagents and giving a higher yield as compared to reported procedures. |
| تدمد: | 0975-427X 0970-7077 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::64278c05ff0131879e01aed94dc0fd64 https://doi.org/10.14233/ajchem.2022.23447 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi...........64278c05ff0131879e01aed94dc0fd64 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 0975427X 09707077 |
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