Prostate stem cell antigen rs2294008 polymorphism differentially contributes to Helicobacter pylori-negative gastric cancer among various populations in China
| العنوان: | Prostate stem cell antigen rs2294008 polymorphism differentially contributes to Helicobacter pylori-negative gastric cancer among various populations in China |
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| المؤلفون: | Li-Juan Wang, Mingzhe Lin, Guoshuang Shen, Jin-Zhang Li, Pai-Li Geng, Sen Cui, Cunfang Shen, Zhanquan Li, Jiuda Zhao, Faxiang Ji, Junhui Zhao, Guoyuan Li |
| المصدر: | Molecular and Clinical Oncology. 1:493-498 |
| بيانات النشر: | Spandidos Publications, 2013. |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | Cancer Research, education.field_of_study, medicine.medical_specialty, biology, business.industry, Mortality rate, Population, Helicobacter pylori, biology.organism_classification, Molecular medicine, Gastroenterology, Prostate Stem Cell Antigen, Oncology, Internal medicine, Genotype, Immunology, medicine, Histopathology, Helicobacter, education, business |
| الوصف: | Gastric cancer is a lethal disease with a high mortality rate. Studies have suggested that prostate stem cell antigen (PSCA) rs2294008 polymorphism is associated with gastric cancer (GC). In this case-control study, we investigated rs2294008 polymorphism in the Tibet, Hui and Han nationalities in the Qinghai area of China. Genomic DNA was extracted from the peripheral blood of 286, 315 and 350 healthy volunteers and from 219, 233 and 265 Helicobacter pylori-negative non-cardia GC patients from the Tibet, Hui and Han populations, respectively. The rs2294008 polymorphism was analyzed by denaturing high-performance liquid chromatography. rs2294008 CT and TT genotypes were associated with GC both in the Tibet and Han populations (adjusted OR=1.51, 1.47, 2.01, 1.85; 95% CI, 1.04–2.19, 1.05–2.06, 1.04–3.88, 1.03–3.34; P=0.030, 0.025, 0.039, 0.040, respectively). rs2294008 TT genotype was associated with GC in the Hui population (adjusted OR=2.14; 95% CI, 1.29–3.55; P=0.003). Furthermore, when stratified by histopathology, the rs2294008 CT and TT genotypes were associated with diffuse GC in the Tibet and Han nationalities (adjusted OR=1.93, 1.73, 2.69, 2.86; 95% CI, 1.09–3.44, 1.01–2.95, 1.06–6.84, 1.27–6.46; P=0.025, 0.045, 0.038, 0.011, respectively). However, the rs2294008 TT genotype was associated with both intestinal and diffuse types of GC (adjusted OR=2.10, 2.21; 95% CI, 1.17–3.75, 1.12–4.38; P=0.012, 0.023, respectively) and the rs2294008 CT genotype was only associated with intestinal-type GC in the Hui nationalitiy group (adjusted OR=1.60; 95% CI, 1.04–2.47; P=0.034). The results therefore showed that rs2294008 may differentially contribute to GC among different nationalities in one area and its role is independent from Helicobacter pylori-infection. |
| تدمد: | 2049-9469 2049-9450 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::643371f837400471bbb36d9e83706acc https://doi.org/10.3892/mco.2013.70 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi...........643371f837400471bbb36d9e83706acc |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20499469 20499450 |
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