التفاصيل البيبلوغرافية
| العنوان: |
Are we there yet? Analyzing scientific research related to COVID-19 drug repurposing |
| المؤلفون: |
Hyeyoung Ryu, Ying Ding, Namu Park, Jeremy J. Yang, Qi Wang, Min Song, Yi Bu, Qi Yu |
| بيانات النشر: |
Research Square Platform LLC, 2020. |
| سنة النشر: |
2020 |
| مصطلحات موضوعية: |
Drug, Drug repositioning, Informetrics, Computer science, media_common.quotation_subject, Spite, Document clustering, Scientometrics, tf–idf, Centrality, Data science, media_common |
| الوصف: |
Drug repurposing may be a pivotal means of fulfilling urgent needs for treatment of the novel coronavirus disease 2019 (COVID-19), but current studies on drug repurposing for COVID-19 seem to show a lack of consensus in their drug candidate focus. Using bibliometric methods in a non-expert perspective, in a review of 34 published articles on the COVID-19 and drug-repurposing, we investigated obvious and less obvious points of consensus on drug candidates. To establish these two types of consensus, we first implemented document clustering. Within a set of five clustered papers, we established an obvious consensus, relying solely on the occurrence of entities by using term frequency and inverse document frequency and a comparison of mentioned drugs, finding that remdesivir and chloroquine were discussed with a certain degree of agreement. For the less obvious consensus, we created a drug entity co-occurrence network to establish low-high centrality combinations to probe the crucial drugs found in article clustering that are not plainly apparent through the mere counting of the occurrence of drug entities occurrences. Lopinavir emerged as having possibly potent effects in spite of underuse, while the mainstream of studies focus more on drugs such as chloroquine that enjoy explicit consent. Using an entitymetrics perspective, we expect that our research will support investigations of drug repurposing, expediting the process of establishing treatment for COVID-19. © 2021 18th International Conference on Scientometrics and Informetrics, ISSI 2021. All rights reserved. |
| URL الوصول: |
https://explore.openaire.eu/search/publication?articleId=doi_________::6567e9b09c44f4cf099185149d471bcb
https://doi.org/10.21203/rs.3.rs-80893/v1 |
| حقوق: |
OPEN |
| رقم الأكسشن: |
edsair.doi...........6567e9b09c44f4cf099185149d471bcb |
| قاعدة البيانات: |
OpenAIRE |
