Synthesis and characterization of Related Substances of Ampicillin – A β-Lactam Antibiotics
| العنوان: | Synthesis and characterization of Related Substances of Ampicillin – A β-Lactam Antibiotics |
|---|---|
| المؤلفون: | chilamkurthi suresh, Dharmasoth Rama Devi, Keloth Basavaiah, Aaramadaka Sunil Kumar Reddy, K. V. V. Prasada rao, Guduri Anil Kumar |
| بيانات النشر: | Research Square Platform LLC, 2023. |
| سنة النشر: | 2023 |
| الوصف: | The present research work narratesthe synthesis, origin and characterization of related substances of Ampicillin trihydrate Viz: Ampicillinyl-d-phenylglycine (Ph. Eur impurity E) & l-Ampicillin (Ph. Eur impurity B). The impurity Ampicillinyl-d-phenylglycine generates during the preparation of Ampicillin trihydrate, amidation may occur with carboxylic acid of Ampicillin with d-phenylglycine to give Ampicillinyl-d-phenylglycine, the impurity l-Ampicillin may arise due to the presence of traces l-phenylglycine methylester in d-phenylglycine methylester hydrochloride which may result in the formation of l-Ampicllin. A facile synthetic process for these impurities was developed from the commercially available raw materials. |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::658ada4fe05e3496ac8f165d55b6d990 https://doi.org/10.21203/rs.3.rs-2684104/v1 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi...........658ada4fe05e3496ac8f165d55b6d990 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |