Differences in HDL-related mortality risk between individuals with and without hypertension: a prospective cohort study in UK Biobank
| العنوان: | Differences in HDL-related mortality risk between individuals with and without hypertension: a prospective cohort study in UK Biobank |
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| المؤلفون: | Jun-Xiang Chen, Rui Li, Tingting Geng, Yuexuan Wang, Qi Lu, Zhou-Zheng Tu, Yue Li, Yun-Fei Liao, Kun Yang, Li-Rong Zhou, Wen-Wei Tong, Yan-Feng Zhou, Gang Liu, An Pan |
| المصدر: | European Journal of Preventive Cardiology. |
| بيانات النشر: | Oxford University Press (OUP), 2023. |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | Epidemiology, Cardiology and Cardiovascular Medicine |
| الوصف: | Background and aimsVery high levels of high-density lipoprotein cholesterol (HDL-C) have been paradoxically linked to increased mortality risk. The present study aimed to examine associations of HDL-C and varied sizes of the HDL particle (HDL-P) with mortality risk stratified by hypertension.Methods and resultsThis prospective cohort study included 429 792 participants (244 866 with hypertension and 184 926 without hypertension) from the UK Biobank. During a median follow-up of 12.7 years, 23 993 (9.8%) and 8142 (4.4%) deaths occurred among individuals with and without hypertension, respectively. A U-shaped association of HDL-C with all-cause mortality was observed in individuals with hypertension after multivariable adjustment, whereas an L-shape was observed in individuals without hypertension. Compared with individuals with normal HDL-C of 50–70 mg/dL, those with very high HDL-C levels (>90 mg/dL) had a significantly higher risk of all-cause mortality among individuals with hypertension (hazard ratio, 1.47; 95% confidence interval, 1.35–1.61), but not among those without hypertension (1.05, 0.91–1.22). As for HDL-P, among individuals with hypertension, a larger size of HDL-P was positively whereas smaller HDL-P was negatively associated with all-cause mortality. After additional adjustment for larger HDL-P in the model, the U-shaped association between HDL-C and mortality risk was altered to an L-shape among individuals with hypertension.ConclusionsThe increased risk of mortality associated with very high HDL-C existed only in individuals with hypertension, but not in those without hypertension. Moreover, the increased risk at high HDL-C levels in hypertension was likely driven by larger HDL-P. |
| تدمد: | 2047-4881 2047-4873 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::66d5f7cf33b718e894d94ad3abaeec5a https://doi.org/10.1093/eurjpc/zwad053 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi...........66d5f7cf33b718e894d94ad3abaeec5a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20474881 20474873 |
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