CPC-014 Analysis of Antiretroviral Therapy in Adult HIV Patients in a Tertiary Hospital
| العنوان: | CPC-014 Analysis of Antiretroviral Therapy in Adult HIV Patients in a Tertiary Hospital |
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| المؤلفون: | A Aranguren Redondo, B. Odriozola Cincunegui, JA Iribarren Loyarte, G Lopez Arzoz, O Valbuena Pascual, MP Bachiller Cacho, P Carmona Oyaga, P Pascual Gonzalez, MJ Gayan Lera, K Andueza Granados |
| المصدر: | European Journal of Hospital Pharmacy. 20:A170.2-A170 |
| بيانات النشر: | BMJ, 2013. |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | Oral treatment, medicine.medical_specialty, Reverse-transcriptase inhibitor, business.industry, virus diseases, Antiretroviral therapy, Surgery, immune system diseases, Background current, Internal medicine, Hiv patients, Medicine, Protease inhibitor (pharmacology), General Pharmacology, Toxicology and Pharmaceutics, Dual therapy, Hospital pharmacy, business, medicine.drug |
| الوصف: | Background Current guidelines (GESIDA/PNS-2012) for antiretroviral therapy (ART) in adults recommend the combination of 3 drugs for the treatment of chronic HIV infection. Purpose To analyse the ART in adult HIV- infected patients monitored in our hospital. Materials and Methods A retrospective and descriptive analysis was conducted at the Outpatient Hospital Pharmacy studying the types of ART in HIV adult patients treated on 1 January 2012. Dates were obtained from the electronic outpatient database. Results 1226 patients were receiving ART. The type of therapy was: monotherapy in 40 patients (3.3%), dual therapy in 37 (3%), triple in 1107 (90.3%), quadruple in 32 (2.6%), quintuple in 7 (0.5%), sixfold in 2 (0.2%) and sevenfold in 1 (0.08%). 156 different treatments were observed with 22 drugs. The most common ART combinations were 2 nucleoside reverse transcriptase inhibitors (NRTI) plus a non-nucleoside reverse transcriptase inhibitor (NNRTI) in 585 patients (47.7%), followed by 2 NRTIs plus a protease inhibitor (PI) in 345 (28.1%) and 3 NRTIs in 75 (6.1%). 43.2% (530) received PI therapy and, mainly, boosted. The combinations tenofovir-emtricitabine or lamivudine-efavirenz were the most frequently prescribed in 358 patients (29.2%), followed by abacavir-lamivudine-efavirenz in 89 (7.3%), tenofovir-emtricitabine-lopinavir-ritonavir in 80 (6.6%), tenofovir-emtricitabine-darunavir-ritonavir in 74 (6%) and abacavir-lamivudine-zidovudine in 72 (5.9%). All patients received oral treatment and 3 of them subcutaneous treatment with the T-20 fusion inhibitor. 621 patients (50.7%) received once-daily treatment (49.3%), 604 twice-daily and one patient three doses daily. Regarding the number of dosage forms, 337 (27.5%) patients were taking one, 273 (22.3%) five, 238 (19.4%) three, 77 (14.4%) were taking two. Conclusions On January 2012, 76% of our hospital HIV patients treated with ART were taking triple combinations of 2 NRTIs + 1 NNRTI or 1 PI. All patients except one received once or twice daily treatment and 42% took 1 or 2 dosage forms/day. No conflict of interest. |
| تدمد: | 2047-9964 2047-9956 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::673b8dbb0d7af783c6fbe7dc76db9e1b https://doi.org/10.1136/ejhpharm-2013-000276.471 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi...........673b8dbb0d7af783c6fbe7dc76db9e1b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20479964 20479956 |
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