Effect of hydrogen peroxide on the sustained release of 99mTc-labeled cytarabine in melanoma of C57 mice by ECT imaging pharmacology
| العنوان: | Effect of hydrogen peroxide on the sustained release of 99mTc-labeled cytarabine in melanoma of C57 mice by ECT imaging pharmacology |
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| المؤلفون: | Yan Han, Qiang Fu, Baofa Yu |
| المصدر: | Journal of Clinical Oncology. 38:e15569-e15569 |
| بيانات النشر: | American Society of Clinical Oncology (ASCO), 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Cancer Research, business.industry, Melanoma, Pharmacology, medicine.disease, Residence time (fluid dynamics), chemistry.chemical_compound, Oncology, chemistry, Cytarabine, medicine, Hydrogen peroxide, Solid tumor, business, medicine.drug |
| الوصف: | e15569 Background: To investigate the residence time of 99mTc-labeled cytarabine in mouse tumors under ECT imaging. Methods: The subcutaneous solid tumor model of mice was established by injection of melanoma cell suspension into the left forelimb of C57 mice. The tumor-bearing mice were divided into treatment group and control group when the longest diameter of the tumor was 5-8 mm. Group 3 only. The mice in the control group were given intratumoral injection of 0.1 ml of 99mTc-labeled cytarabine solution, and the mice in the treatment group were given intratumoral injection 0.1 ml 99mTc labeled cytarabine combined with hydrogen peroxide solution at 0.25 h, 0.5 h, 1 h. After 2 hours and 19 hours of administration, the radioactivity intensity values were observed by SPECT Apx-409 ECT phenomenon equipment. Results: The T/W values of ECT imaging in 3 mice in the treatment group were higher than those in the control group at 0.25 h, 0.5 h, 1 h, 2 h and 19 h. The T/W values of ECT imaging decreased in the treatment group at different time points. The amplitude was lower, and the T/W values in each period were higher than those in the control group. Conclusions: The sustained release agent hydrogen peroxide can significantly increase the residence time of 99mTc-labeled cytarabine in the tumor. It is speculated that hydrogen peroxide has a positive effect on prolonging the drug action time of cytarabine and improving the effect of killing tumor cells. It showed that H2O2 can hold the Ara-C for a long time in tumor. |
| تدمد: | 1527-7755 0732-183X |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::67ad9b51983e9751267562f30d2cc7d6 https://doi.org/10.1200/jco.2020.38.15_suppl.e15569 |
| رقم الأكسشن: | edsair.doi...........67ad9b51983e9751267562f30d2cc7d6 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15277755 0732183X |
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