The article presents the results of research on the effectiveness of microbiologic specimen against the background of various doses of mineral fertilizers, and without them. The results were obtained in two short-term experiments for the period from 2015 to 2018.Goal of research: to increase the productivity and quality of potatoes with the integrated use of full and reduced by 30 and 50% doses of mineral fertilizers in combination with various microbiologic specimen by increasing the biological activity of the soil and better nutrient absorption.In the field test (2015-2016, sod-podzolic sandy soil), the yield of potatoes was 24.1-27.9 t / ha (when using mineral fertilizers N 45-90 P 45-90 K 60-120 ). When N 45 P 45 K 60 was combined with preplant treatment of tubers with microbiologic specimen (Azolen, Agrinos «1» and Biocomposite-correct), it increased by 27.6-28.5%, including the increase from microbiologic specimen - 3.5-4.4 t / ha or 14.5-18.3%. In the field test (2016 and 2017-2018, sod-podzolic sandy soil), the maximum yield of potatoes (34.0-35.7 t / ha) was obtained using the microbiologic specimen Extrasol both separately for preplant treatment of tubers, and in combination with foliar application of Agrinos «2» and Extrasol on the background of the full dose of fertilizers N 90 P 90 K 90 . In this case, the yield increase from the biologic specimen was 6.5-8.2 t / ha or 23.6-29.8%.In the variant with a 30% reduced NPK dose and the use of Agrinos [N 60 P 60 K 60 + Agrinos 1+2 (5+2.5 l / ha)]: the yield level was 4.6 t / ha (17%) higher a full dose of NPK. At the same time high starchiness and vitamin C content, excellent culinary qualities, low levels of nitrates in products; conditional income was 42.3 thousand rubles / ha higher than NPK background, low cost (6.8 rubles / kg), high cost recovery (3.25) and profitability of production 64% were observed.