Correlation of FOXA1 with some clinicopathological features, lymph node, grade, stage and tumor size
| العنوان: | Correlation of FOXA1 with some clinicopathological features, lymph node, grade, stage and tumor size |
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| المؤلفون: | Mohammed A. Mohsin, Karrar S. Zayed |
| المصدر: | International journal of health sciences. :3568-3578 |
| بيانات النشر: | Universidad Tecnica de Manabi, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | General Nursing, Education |
| الوصف: | The Forkhead box (FOX) protein family includes FOXA1, and is a transcription factor (TF). It work as a pioneer factor, interacting with compressed chromatin to allow ER to bind more easily later (Nagaraj and Ma, 2021). It significantly contributed to the development and invasiveness of endocrine-resistant cells by changing the ER dependent transcriptome in numerous endocrine-resistant preclinical BC cell types (Chun et al., 2017). The present study is done during the period September 2021 and May 2022 at the University of Kufa's, Faculty of Medicine, Middle Euphrates Unit for Cancer Research. as a control group. These samples gathered from archives of the two private laboratories and re-evaluted by two pathologist. Positive nuclear IHC expression of FOXA1 is significantly reduced in 43 BC cases (58.9%) compared to 38 control persons (100%) while negative nuclear IHC expression of FOXA1 is significantly reduced in BC patients, 30 cases (41.1%) compared to 0 control persons (0.0%), Odd ratio 1.66, 95% CI (1.37-1.98), P=0.0001. Moreover, FOXA1 positivity was elevated significantly in patients with grade I and II (P=0.002) and absent of lymph node metastasis (p=0.027). |
| تدمد: | 2550-696X 2550-6978 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::6948aba908ceaaedffe33e3812714246 https://doi.org/10.53730/ijhs.v6ns7.12574 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi...........6948aba908ceaaedffe33e3812714246 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 2550696X 25506978 |
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