The role of cohabitation on adaptive and innate immune cell profiles in the Health and Retirement Study
العنوان: | The role of cohabitation on adaptive and innate immune cell profiles in the Health and Retirement Study |
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المؤلفون: | Ramya Ramasubramanian, Helen Meier, Eileen Crimmins, Jessica Faul, Bharat Thyagarajan |
المصدر: | American Journal of Clinical Pathology. 158:S2-S2 |
بيانات النشر: | Oxford University Press (OUP), 2022. |
سنة النشر: | 2022 |
مصطلحات موضوعية: | General Medicine |
الوصف: | Immune cells distribution is shaped by numerous factors including environmental factors, age, and genetics. Cohabitation has been associated with similar microbiomes, possibly due to dietary patterns and exposure to similar pathogens but has not been studied in the context of adaptive and innate immune systems previously. We used immunophenotyping data of 2283 households with participants living in the same household and compared it to 2283 randomly generated pairs of participants from the Health and Retirement study. The adaptive immune cells (subsets of T-cells and B-cells), and innate immune cells (monocytes, natural killer cells, and neutrophils) were compressed to two coordinates using multidimensional scaling. The Euclidean distances between participants in the same household were compared to the distances between the random pairs of participants using two sample independent t-tests. The mean distances of the immune coordinate points for adaptive immune cells between participants in the same household were lower than the randomly paired participants (p-value < 0.0001) and the variability of intra-household distances was lower than the random pairs (IQR: 7.18 vs 8.99). For the innate immune cells, the mean distances between participants in the same household were slightly lower than the randomly paired participants (p-value = 0.03) but the variability of the intra-household distances was higher than the random pairs (IQR: 4.08 vs 3.65). Variability in the adaptive immune system among participants living in the same household were substantially lower indicating the influence of shared environmental conditions in determining the adaptive immune profiles. |
تدمد: | 1943-7722 0002-9173 |
URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::6ca37b94569767217daaafb4f6d837d2 https://doi.org/10.1093/ajcp/aqac126.002 |
حقوق: | CLOSED |
رقم الأكسشن: | edsair.doi...........6ca37b94569767217daaafb4f6d837d2 |
قاعدة البيانات: | OpenAIRE |
تدمد: | 19437722 00029173 |
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