Serum Krebs von den Lungen-6 and lung ultrasound B lines as potential diagnostic and prognostic factors for rheumatoid arthritis–associated interstitial lung disease
| العنوان: | Serum Krebs von den Lungen-6 and lung ultrasound B lines as potential diagnostic and prognostic factors for rheumatoid arthritis–associated interstitial lung disease |
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| المؤلفون: | Asrar Helal, Dina Salem Fotoh, Heba A. Esaily, Mohamed S Rizk |
| المصدر: | Clinical Rheumatology. 40:2689-2697 |
| بيانات النشر: | Springer Science and Business Media LLC, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | medicine.medical_specialty, behavioral disciplines and activities, Gastroenterology, Asymptomatic, Pulmonary function testing, 03 medical and health sciences, FEV1/FVC ratio, 0302 clinical medicine, Rheumatology, Internal medicine, medicine, 030212 general & internal medicine, Prospective cohort study, 030203 arthritis & rheumatology, business.industry, Interstitial lung disease, General Medicine, respiratory system, medicine.disease, respiratory tract diseases, Lung ultrasound, body regions, Rheumatoid arthritis, medicine.symptom, business |
| الوصف: | Rheumatoid arthritis (RA)–associated interstitial lung disease (ILD) (RA-ILD) is a serious systemic RA manifestation with high mortality that needs proper, accurate, and sensitive assessment tools. Firstly, evaluate serum Krebs von den Lungen-6 (KL-6) levels and lung ultrasound B lines (LUS B lines) score in RA-ILD correlating them with the severity of ILD assessed by high-resolution computed tomography (HRCT) and pulmonary function tests (PFTs). Secondly, determine cut-off values for LUS and KL-6 in RA-ILD assessment and outcome prediction. A case-control study included seventy-five RA-ILD patients with an equal number of matched RA patients without ILD. Clinical assessment includes DAS-28 and PFTs, laboratory assessment of serum KL-6 by latex-enhanced immunoturbidimetric assay, and radiological evaluation of ILD using semiquantitative CT grade and LUS B lines. RA-ILD patients had significantly higher serum KL6 compared to those without ILD (1025.5 ± 419.6 vs. 237.5 ± 51.9, p ≤ 0.001). Serum KL6 was positively correlated with HRCT and LUS scores (r = 0.93, r = 0.97, respectively) with negative correlation with FVC% and FEV1% (r = − 0.93, r = − 0.91, respectively). LUS was positively correlated with KL6 and HRCT (r = 0.97, r = 0.944, respectively) while, negatively correlated with PFTs. Cut-off values of KL6 and LUS were 277.5 U/ml and |
| تدمد: | 1434-9949 0770-3198 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::6cd111a2bdd3d091f0fd3db2b000e645 https://doi.org/10.1007/s10067-021-05585-y |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi...........6cd111a2bdd3d091f0fd3db2b000e645 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 14349949 07703198 |
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