Prognostic Value of Tumor Staging: Predicting Nodal Metastases in Cutaneous Squamous Cell Carcinoma
| العنوان: | Prognostic Value of Tumor Staging: Predicting Nodal Metastases in Cutaneous Squamous Cell Carcinoma |
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| المؤلفون: | Maie A. St. John, Jason V Scapa, Ashley Kita, Montana Upton |
| المصدر: | The Laryngoscope. 131 |
| بيانات النشر: | Wiley, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | medicine.medical_specialty, Cutaneous squamous cell carcinoma, business.industry, medicine.medical_treatment, Cancer, Neck dissection, Tumor Staging, medicine.disease, Tumor excision, 030207 dermatology & venereal diseases, 03 medical and health sciences, 0302 clinical medicine, Otorhinolaryngology, 030220 oncology & carcinogenesis, medicine, Radiology, Head and neck, NODAL, business, AJCC staging system |
| الوصف: | OBJECTIVES Determine the ability of three staging systems to stratify the risk of nodal metastases in cases of cutaneous squamous cell carcinoma (cSCC). Examine differential staging of tumors across the three systems and the resulting implications for clinical decision making. STUDY DESIGN Retrospective chart review. METHODS This study included 118 patients who underwent excision of primary cSCC of the head and neck as well as elective neck dissection for the same tumor between 2006 and 2017. Tumors were staged using the 2010 7th edition American Joint Committee on Cancer (AJCC 7) staging system, the 2016 8th edition AJCC staging system (AJCC 8), and the Brigham and Women's Hospital (BWH) alternative tumor staging system published in 2013. RESULTS There were 28 patients (23.7%) with positive nodal metastases at the time of tumor excision. Almost all tumors staged as tumor (T)2 using AJCC 7 were upstaged to T3 or T4 using the new AJCC 8, and these two groups accounted for the majority of the nodal metastases. Similarly, the BWH-staged T3 group contained the highest number of tumors with nodal metastases. None of the three staging systems significantly stratified tumors in a manner that predicted the presence of nodal metastases. CONCLUSION Individuals with cSCC tumors staged T3 or higher in the AJCC 8 and BWH staging systems should undergo neck dissection, whereas those with lower staging should be discussed with the patient on a case-by-case basis. LEVEL OF EVIDENCE 4. |
| تدمد: | 1531-4995 0023-852X |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::6e6a8be7c83916dde98b49121cf5b9c8 https://doi.org/10.1002/lary.28633 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi...........6e6a8be7c83916dde98b49121cf5b9c8 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15314995 0023852X |
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