Comparative efficacy of oral traditional Chinese patent medicines for acute cerebral infarction: A protocol for a systematic review and network meta-analysis
| العنوان: | Comparative efficacy of oral traditional Chinese patent medicines for acute cerebral infarction: A protocol for a systematic review and network meta-analysis |
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| المؤلفون: | Xing Liao, Dan-Dan Yu, Hui Zhao, Jun Zhao, Rui-Zhao Cui, Nicola Robinson |
| المصدر: | European Journal of Integrative Medicine. 32:100977 |
| بيانات النشر: | Elsevier BV, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Protocol (science), medicine.medical_specialty, business.industry, education, MEDLINE, Cochrane Library, Chinese patent, 030205 complementary & alternative medicine, law.invention, 03 medical and health sciences, 0302 clinical medicine, Systematic review, Complementary and alternative medicine, Randomized controlled trial, law, Meta-analysis, Acute cerebral infarction, medicine, 030212 general & internal medicine, Intensive care medicine, business |
| الوصف: | Introduction Traditional Chinese patent medicines (TCPMs) are widely used in the treatment of acute cerebral infarction (ACI) in China. Many oral traditional Chinese patent medicines have been reported to be effective for ACI. However, a comparison of randomized controlled trials (RCTs) to directly compare the efficacy of the different oral TCPMs has not been performed. There is no evidence to demonstrate which of oral TCPMs are more effective for clinicians. Therefore, we plan to conduct a systematic review and network meta-analysis (NMA) to compare the efficacy of 10 kinds of oral TCPMs for ACI. The aim is to provide the best currently available evidence base to guide the selection of oral TCPMs. Methods A systematic and comprehensive search will be performed from inception to July 2019 in both English and Chinese databases, involving Medline, Cochrane Library, Embase, China National Knowledge Infrastructure Database, Wanfang Database, Chongqing VIP information, and SinoMed. All RCTs related to TCPMs in the treatment of ACI will be included. The primary outcomes are mortality, as well as the the rate of cerebrovascular event including a recurrence event. The secondary outcomes include National Institutes of Health Stroke Scale and adverse drug reactions/adverse drug events. Two reviewers will independently screen the literature by using pre-specified eligibility criteria, and assess the quality of included studies according to the risk of bias tool of Cochrane Handbook 5.1.0. The GRADE approach will be used to rate the quality of evidence of estimates derived from NMA. Data analysis will be conducted by using STATA13.0 and WinBUGS1.4.3. Results This systematic review and NMA aims to summarize the direct and indirect evidence for 10 kinds of oral TCPMs and to rank these TCPMs. The findings of this NMA will be reported according to PRISMA-NMA statement. The results of the NMA will be submitted to a peer-reviewed journal once completed. Conclusion Using NMA, this study will offer new and informative evaluations of current TCPMs for ACI. The results will inform clinicians, provide optimal clinical treatment strategies, bridge the evidence gaps, and identify promising TCPMs for evaluation in future trials. The protocol has been registered on PROSPERO (International Prospective Register of Systematic Reviews) (CRD42018110307). |
| تدمد: | 1876-3820 4201-8110 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::70464568f0b6c7e4c5134a7856d7e0bd https://doi.org/10.1016/j.eujim.2019.100977 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi...........70464568f0b6c7e4c5134a7856d7e0bd |
| قاعدة البيانات: | OpenAIRE |
Full Text via ClinicalKey | تدمد: | 18763820 42018110 |
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