Deleterious Protein-Protein Interactions (PPIs) involving Ras-related proteins have been known to play significant roles in events leading to cellular proliferation, inhibition of cell death, and cell transformation. Therefore, it is important to characterize molecular features of Ras protein interactions that dictate their function as ‘timing switches’ in signal transduction pathways. This is a critical step towards targeting the inhibition of cell transformation as well as controlling abnormal signaling activity of tumor-causing Ras variants.
