Evaluation of protective effects of mirtazapine and mesna on cisplatin-induced ovarian damage in rats
| العنوان: | Evaluation of protective effects of mirtazapine and mesna on cisplatin-induced ovarian damage in rats |
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| المؤلفون: | Abdülmecit Öktem, Murat Alan, Ali Doğukan Anğın, Önder Sakin, Yasemin Alan, Asuman Orçun Kaptanağasi, Muzaffer Seyhan Çıkman, Muhammet Ali Oruç, Kayhan Başak, Emine Eda Akalin |
| المصدر: | Journal of Experimental and Clinical Medicine. 38:72-81 |
| بيانات النشر: | Ondokuzmayis University, Faculty of Medicine, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Cisplatin, endocrine system, biology, business.industry, Mirtazapine, Anti-Müllerian hormone, Ovary, General Medicine, Pharmacology, General Biochemistry, Genetics and Molecular Biology, medicine.anatomical_structure, medicine, biology.protein, business, Mesna, medicine.drug |
| الوصف: | To evaluate whether mirtazapine and mesna have protective effects on cisplatin-induced ovarian injury. A total of 32 female Wistar Albino rats were divided into 4 groups (8 rats per group) and included in the study. No medication was administered to the first group; only intervention was that their ovaries were removed and anti-mullerian hormone (AMH) values were measured. The second group received intramuscular cisplatin at a single dose of 7.5 mg/kg. The third group received a single dose of 200 mg/kg mesna intraperitoneally, and 30 minutes later, a single dose of 7.5 mg/kg intramuscular cisplatin was administered. The fourth group received oral 30 mg/kg mirtazapine, and 60 minutes later, a single dose of 7.5 mg/kg intramuscular cisplatin was administered. Oral 30 mg/kg mirtazapine was continued for ten days. Ovaries and AMH values of all groups were evaluated at the end of tenth day. In the cisplatin group when compared to normal ovarian tissue total histopathological damage score increased (p=0.037), preantral follicle count decreased (p=0.003) and AMH levels decreased (p |
| تدمد: | 1309-5129 1309-4483 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::7138c74620376885c2d1e27648862c76 https://doi.org/10.52142/omujecm.38.2.4 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi...........7138c74620376885c2d1e27648862c76 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13095129 13094483 |
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