Intravoxel incoherent motion diffusion-weighted MRI for the characterization of inflammation in chronic liver disease
| العنوان: | Intravoxel incoherent motion diffusion-weighted MRI for the characterization of inflammation in chronic liver disease |
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| المؤلفون: | An Tang, Marie-Pierre Sylvestre, Guillaume Gilbert, Giada Sebastiani, Mélanie Hébert, Damien Olivié, Milena Cerny, Laurent Bilodeau, Thierry Lefebvre, Zu-Hua Gao, Guy Cloutier, Bich N. Nguyen |
| المصدر: | European Radiology. 31:1347-1358 |
| بيانات النشر: | Springer Science and Business Media LLC, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | medicine.medical_specialty, medicine.diagnostic_test, Receiver operating characteristic, business.industry, Intraclass correlation, General Medicine, medicine.disease, Chronic liver disease, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, 0302 clinical medicine, Fibrosis, 030220 oncology & carcinogenesis, Liver biopsy, Nonalcoholic fatty liver disease, medicine, Radiology, Nuclear Medicine and imaging, Radiology, Nuclear medicine, business, Intravoxel incoherent motion, Diffusion MRI |
| الوصف: | To evaluate the diagnostic performance of intravoxel incoherent motion (IVIM) diffusion-weighted imaging (DWI) for grading hepatic inflammation. In this retrospective cross-sectional dual-center study, 91 patients with chronic liver disease were recruited between September 2014 and September 2018. Patients underwent 3.0-T MRI examinations within 6 weeks from a liver biopsy. IVIM parameters, perfusion fraction (f), diffusion coefficient (D), and pseudo-diffusion coefficient (D*), were estimated using a voxel-wise nonlinear regression on DWI series (10 b-values from 0 to 800 s/mm2). The reference standard was histopathological analysis of hepatic inflammation grade, steatosis grade, and fibrosis stage. Intraclass correlation coefficients (ICC), univariate and multivariate correlation analyses, and areas under receiver operating characteristic curves (AUC) were assessed. Parameters f, D, and D* had ICCs of 0.860, 0.839, and 0.916, respectively. Correlations of f, D, and D* with inflammation grade were ρ = − 0.70, p |
| تدمد: | 1432-1084 0938-7994 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::7211e07ca0a644241e0015070ab97348 https://doi.org/10.1007/s00330-020-07203-y |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi...........7211e07ca0a644241e0015070ab97348 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 14321084 09387994 |
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