التفاصيل البيبلوغرافية
| العنوان: |
A guide on gene prioritization in studies of psychiatric disorders |
| المؤلفون: |
Wim van den Brink, Julia F. van den Berg, Eske M. Derks, Kim C Cerrone, Sven Stringer, René S. Kahn, Damiaan Denys |
| المصدر: |
International Journal of Methods in Psychiatric Research. 24:245-256 |
| بيانات النشر: |
Wiley, 2015. |
| سنة النشر: |
2015 |
| مصطلحات موضوعية: |
Psychiatry and Mental health, medicine.medical_specialty, Sample size determination, medicine, Identification (biology), Genome-wide association study, Cognition, Introduction to genetics, Psychiatry, Psychology, Association (psychology), Selection (genetic algorithm), Genetic association |
| الوصف: |
There has been an increasing interest in the identification of genetic variants causing individual differences in human behavior. Psychiatrists have contributed to the genetics field by defining the most important behavioral characteristics and by studying the association between genetic variants and behavioral differences within phenotypically well-characterized samples in which detailed assessments have been collected (e.g. neuroimaging). These samples are typically limited in size and are therefore not suitable for a genome-wide association analysis. Instead, gene association studies conducted in such samples typically focus on a few genes of interest, allowing smaller sample sizes. However, the selection of high-priority genes is not always straightforward and psychiatrists will usually have a limited background in genetics. We aim to fill this gap by (i) providing a basic introduction to genetics; (ii) showing how the selection of genes of interest can be optimized by the use of two web tools: Polysearch and Gene Prospector; (iii) illustrating how statistical power analyses can be performed and discussing the importance of sufficiently powered studies. This guide can help psychiatrists with limited experience in genetics in designing genetic studies that allow identification of specific behavioral, cognitive, or neural correlates of genetic risk variants, while avoiding common pitfalls. Copyright © 2015 John Wiley & Sons, Ltd. |
| تدمد: |
1049-8931 |
| URL الوصول: |
https://explore.openaire.eu/search/publication?articleId=doi_________::7224df3373f3f56309a3b54a1b8b310c
https://doi.org/10.1002/mpr.1482 |
| حقوق: |
OPEN |
| رقم الأكسشن: |
edsair.doi...........7224df3373f3f56309a3b54a1b8b310c |
| قاعدة البيانات: |
OpenAIRE |
