In fusion research the ability to generate and sustain high performance fusion plasmas gains more and more importance. Optimal combinations of magnetic shape, temperature and density profiles as well as the confinement time are identified as advanced regimes. Safe operation in such regimes will be crucial for the success of ITER and later fusion reactors. The operational space, on the other hand, is characterized by nonlinear dependencies between plasma parameters. Various MHD limits must be avoided in order to minimize the risk of a disruption. Sophisticated feedback control schemes help to tackle this challenge. But these in turn require detailed information on plasma state in time to allow proper reaction. Control system and diagnostic systems therefore must establish a symbiotic relationship to carry out such schemes. Today, all major fusion devices implement such a concept. An implementation of such a concept with sustained integration is presented using the example of ASDEX Upgrade. It covers data communication via a real-time network, synchronization mechanisms for data-driven algorithm execution as well as operational aspects and exception handling for failure detection and recovery. A modular distributed software framework offers standardized user algorithm interfaces, automated workflow procedures and the application of various computer and network hardware components. Designed with a special focus on reliability, robustness and flexibility, it is a sound base for exploring ITER-relevant plasma regimes and control strategies.