Synthesis and Biological Activity of Novel Zinc-Itraconazole Complexes in Protozoan Parasites and Sporothrix spp
| العنوان: | Synthesis and Biological Activity of Novel Zinc-Itraconazole Complexes in Protozoan Parasites and Sporothrix spp |
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| المؤلفون: | Sara Teixeira de Macedo Silva, Jose Aleixo de Azevedo-França, Emile Barrias, Maribel Navarro, Sandra Mara Naressi Scapin, Renato Granado, Luana Pereira Borba-Santos, Juliany Cola Fernandes Rodrigues, Erica S. Martins-Duarte, Gabrielle Dos Santos-Silva, Wanderley de Souza, Sonia Rozental |
| المصدر: | Antimicrobial Agents and Chemotherapy. 64 |
| بيانات النشر: | American Society for Microbiology, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Pharmacology, chemistry.chemical_classification, biology, 010405 organic chemistry, Itraconazole, Chemistry, Antiparasitic, medicine.drug_class, chemistry.chemical_element, Biological activity, Sporothrix, Zinc, 010402 general chemistry, biology.organism_classification, 01 natural sciences, 0104 chemical sciences, Infectious Diseases, medicine, Azole, Sporothrix schenckii, Pharmacology (medical), Trypanosoma cruzi, medicine.drug, Nuclear chemistry |
| الوصف: | The new complexes Zn(ITZ) 2 Cl 2 (1) and Zn(ITZ) 2 (OH) 2 (2) were synthetized by a reaction of itraconazole with their respective zinc salts under reflux. These Zn-ITZ complexes were characterized by elemental analyses, molar conductivity, mass spectrometry, 1 H and 13 C{ 1 H} nuclear magnetic resonance, and UV-vis and infrared spectroscopies. The antiparasitic and antifungal activity of Zn-ITZ complexes was evaluated against three protozoans of medical importance, namely, Leishmania amazonensis , Trypanosoma cruzi , and Toxoplasma gondii , and two fungi, namely, Sporothrix brasiliensis and Sporothrix schenckii . |
| تدمد: | 1098-6596 0066-4804 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::73e2d943b91d0b9b495ad1b1db6e5466 https://doi.org/10.1128/aac.01980-19 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi...........73e2d943b91d0b9b495ad1b1db6e5466 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10986596 00664804 |
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