Development of the cephalosporin C fermentation taking into account the instability of cephalosporin C
| العنوان: | Development of the cephalosporin C fermentation taking into account the instability of cephalosporin C |
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| المؤلفون: | Bruce Jon Compton, Doris W. Hughes, John J. Usher, MaryAnn Lewis |
| المصدر: | Biotechnology Letters. 10:543-548 |
| بيانات النشر: | Springer Science and Business Media LLC, 1988. |
| سنة النشر: | 1988 |
| مصطلحات موضوعية: | Strain (chemistry), medicine.drug_class, Chemistry, Stereochemistry, Cephalosporin, Antibiotics, Bioengineering, General Medicine, Cephalosporin C, Applied Microbiology and Biotechnology, Hydrolysis, chemistry.chemical_compound, polycyclic compounds, medicine, Lactam, Fermentation, Chemical decomposition, Biotechnology |
| الوصف: | Cephalosporin C undergoes chemical hydrolysis during fermentation at 25°C at a rate of 0.48% per hour to give increasing amounts of 2-(D-4-amino-4-carboxybutyl)thiazole-4-carboxylic acid (compound X). Although the cephalosporin C titer in a fermentation levels off at 160–170h, the total of C+X rises almost linearly up to 200h. Cells, therefore, biosynthesize cephalosporin C at an almost constant rate up to 200h. This instability greatly influences attempts to improve the cephalosporin strain by genetic manipulation, or the process by alterations in technology. |
| تدمد: | 1573-6776 0141-5492 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::741407342d3315bbe3a0f8f39c452f24 https://doi.org/10.1007/bf01027126 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi...........741407342d3315bbe3a0f8f39c452f24 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 15736776 01415492 |
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