This study aimed to investigate perfectionism among talented students and its relationship to their self-esteem. Eighty-nine male and female talented students in King Abdullah II Schools for Excellence in Jordan were administered. Big Three Perfectionism Scale and Self-Esteem Scale to Rosenberg were used based on arithmetic mean, standard deviations, T-test for independent samples and Pearson correlation. The results indicate that the levels of three types of perfectionism and self-esteem are medium among students of King Abdullah II Schools for Excellence; also, there are no statistically significant differences between male and female students on Rigid Perfectionism and Narcissistic Perfectionism, while there are statistically significant differences between male and female students in Self-Critical Perfectionism and there are no statistically significant differences for Pearson Correlation to Rigid Perfectionism and Narcissistic Perfectionism on self-esteem; however, there are negative statistically significant differences for Pearson Correlation to Self-critical Perfectionism on self-esteem. Keywords: Perfectionism, self-esteem, talented students.