In Vivo Overexpression of Dad1, the Defender Against Apoptotic Death-1, Enhances T Cell Proliferation But Does Not Protect Against Apoptosis
| العنوان: | In Vivo Overexpression of Dad1, the Defender Against Apoptotic Death-1, Enhances T Cell Proliferation But Does Not Protect Against Apoptosis |
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| المؤلفون: | N. A. Hong, N. H. Kabra, S. N. Hsieh, D. Cado, A. Winoto |
| المصدر: | The Journal of Immunology. 163:1888-1893 |
| بيانات النشر: | The American Association of Immunologists, 1999. |
| سنة النشر: | 1999 |
| مصطلحات موضوعية: | Immunology, Immunology and Allergy |
| الوصف: | The Dad1 protein has been shown to play a role in prevention of apoptosis in certain cell types. Dad1 is also a subunit of the oligosaccharyltransferase enzyme complex that initiates N-linked glycosylation. It is encoded by a gene located adjacent to the TCR α and δ genes on mouse chromosome 14. We have investigated the role of Dad1 during T cell development and activation. We observe that endogenous Dad1 levels are modulated during T cell development to reach maximal expression in mature thymocytes. Transgenic mice that overexpress Dad1 in both the thymus and peripheral immune system have been generated. Apoptosis of thymocytes from such mice is largely unaffected, but peripheral T cells display hyperproliferation in response to stimuli. Therefore, the linkage between the TCR and Dad1 genes may have important consequences for T cell function. |
| تدمد: | 1550-6606 0022-1767 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::754ca66f1ef37b019d8129f98761f7bc https://doi.org/10.4049/jimmunol.163.4.1888 |
| رقم الأكسشن: | edsair.doi...........754ca66f1ef37b019d8129f98761f7bc |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15506606 00221767 |
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