3D Nanoprinted Liquid-Core-Shell Microparticles
| العنوان: | 3D Nanoprinted Liquid-Core-Shell Microparticles |
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| المؤلفون: | Stephen W. Hoag, Sharon Flank, Michael A. Restaino, Ryan D. Sochol, Dongyue Yu, Ruben Acevedo |
| المصدر: | Journal of Microelectromechanical Systems. 29:924-929 |
| بيانات النشر: | Institute of Electrical and Electronics Engineers (IEEE), 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Fabrication, Materials science, Mechanical Engineering, Analytical chemistry, Shell (structure), 02 engineering and technology, 010402 general chemistry, 021001 nanoscience & nanotechnology, 01 natural sciences, 0104 chemical sciences, Core (optical fiber), Turn (geometry), Particle, Particle size, Electrical and Electronic Engineering, Microparticle, 0210 nano-technology, Body orifice |
| الوصف: | The ability to fabricate core-shell microparticles with high control over the three-dimensional (3D) microarchitecture of each particle offers unique potential to advance applications such as cell/tissue engineering, diagnostics, and drug delivery. Despite significant progress, current barriers include undesired polydispersity ( e.g. , for particle size and shape) as well as limited design customization with respect to the 3D geometric complexity of individual microparticles. To address such challenges, here we introduce a novel strategy that leverages the submicron-scale additive manufacturing (or “3D printing”) technology, “direct laser writing (DLW)”, to fabricate core-shell microparticles with liquid-phase cores and individually tunable shell architectures. This approach consists of three fundamental steps: ( ${i}$ ) DLW-based printing of a photomaterial shell with a top orifice, ( ii ) vacuum-loading of a liquid-phase core, and then ( iii ) DLW-based printing of a “cap” atop the orifice to complete the shell (while sealing the core). In this work, we investigated the relationships between the initial shell orifice size and microfluidic core encapsulation efficacy. Fabrication and experimental results for microfluidic vacuum-loading of cores comprising a methylene blue-dyed aqueous solution revealed that shell orifice diameters ( ${D}$ ) of $1.71\pm 0.14~\mu \text{m}$ exhibited poor core-loading performance, whereas ${D} \geq 3.61\pm 0.13~\mu \text{m}$ all led to effective core-loading. Results for fluorescence quantification after the final encapsulation step, however, revealed that each increase of approximately $2~\mu \text{m}$ in ${D}$ from $3.61\pm 0.13~\mu \text{m}$ up to $11.69\pm 0.16~\mu \text{m}$ corresponded to a significant reduction in retention performance of the microfluidic core. In combination, the presented methodology opens new avenues for core-shell microparticle design and manufacturing, and in turn, emerging applications enabled by such capabilities. [2020-0118] |
| تدمد: | 1941-0158 1057-7157 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::75ff33ccd83e44619e06817bb7f9158c https://doi.org/10.1109/jmems.2020.3000479 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi...........75ff33ccd83e44619e06817bb7f9158c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19410158 10577157 |
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