Prospects for the use of new generation of anti-tuberculosis drugs in treatment of drug-resistant tuberculosis
| العنوان: | Prospects for the use of new generation of anti-tuberculosis drugs in treatment of drug-resistant tuberculosis |
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| المؤلفون: | Natalia Zabolotnykh, Marine Dogonadze, Mariia V. Pavlova, Elena Ershova, Petr K. Yablonsky, Irina Chernokhaeva, Nadezhda Sapozhnikova, Tatiana Vinogradova, Mariia L. Vitovskaya, Alevtina N. Grishko, Liudmila Archakova, Anna Starshinova |
| المصدر: | Reviews on Clinical Pharmacology and Drug Therapy. 18:115-121 |
| بيانات النشر: | ECO-Vector LLC, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Drug, Tuberculosis, biology, business.industry, media_common.quotation_subject, Drug resistant tuberculosis, General Medicine, Drug resistance, Pharmacology, biology.organism_classification, medicine.disease, Mycobacterium tuberculosis, chemistry.chemical_compound, chemistry, medicine, Bedaquiline, Medical prescription, business, Pathogen, media_common |
| الوصف: | The aim of this work was an experimental and clinical study of increasing of the efficiency of therapy of respiratory tuberculosis with drug resistant pathogen by including a combination of anti-tuberculosis drugs of new generation Bedaquiline (Bq) and Thioureidoiminomethylpyridi-nium perchlorate (perchlozone, Tpp) into treatment regimens. The presented results were obtained: in the experiment on a model of tuberculosis infection in 103 male C57black / 6 mice, reproduced by inserting into the lateral vein of the tail of a suspense of clinical strains of Mycobacterium tuberculosis with multi-drug resistance (MDR) and with various combinations of mutations in the genes; in the clinic on the basis of examination and treatment of 148 patients with multidrug-resistant respiratory tuberculosis. It is shown that the application of the therapy schemes for multiple and broad drug resistant tuberculosis, containing Bq and Tpp in combination with drugs, selected taking into account the drug sensitivity of mycobacteria, allows to significantly reduce the periods of relief of symptoms of intoxication, regression of inflammatory changes, abacillation and achieving positive X-ray dynamics. Undesirable phenomena against the background of combined prescription of new generation drugs, as a rule, corresponded to light and moderate severity, and in frequency of development and expression did not differ from control groups of observation. |
| تدمد: | 2542-1875 1683-4100 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::76a1072d149a81ad907d662a78913420 https://doi.org/10.17816/rcf182115-121 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi...........76a1072d149a81ad907d662a78913420 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 25421875 16834100 |
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