Role of the gut–skin axis in IgE-mediated food allergy and atopic diseases
| العنوان: | Role of the gut–skin axis in IgE-mediated food allergy and atopic diseases |
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| المؤلفون: | Kewin Tien Ho Siah, Elizabeth Huiwen Tham, Noor H. A. Suaini |
| المصدر: | Current Opinion in Gastroenterology. 37:557-564 |
| بيانات النشر: | Ovid Technologies (Wolters Kluwer Health), 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | business.industry, medicine.medical_treatment, Gastroenterology, Atopic dermatitis, Immunotherapy, medicine.disease, Allergic inflammation, Clinical trial, Immune system, Food allergy, Immunology, Medicine, Microbiome, business, Asthma |
| الوصف: | Purpose of review In recent years, landmark clinical trials investigating the role of early oral exposure to food antigens for food allergy (FA) prevention have highlighted the importance of immunoregulatory pathways in the 'gut-skin axis'. This review highlights recent literature on the mechanisms of the immune system and microbiome involved in the gut-skin axis, contributing to the development of atopic dermatitis (AD), FA, allergic rhinitis (AR) and asthma. Therapeutic interventions harnessing the gut-skin axis are also discussed. Recent findings Epicutaneous sensitization in the presence of AD is capable of inducing Th2 allergic inflammation in the intestinal tract and lower respiratory airways, predisposing one to the development of AR and asthma. Probiotics have demonstrated positive effects in preventing and treating AD, though there is no evident relationship of its beneficial effects on other allergic diseases. Prophylactic skin emollients use has not shown consistent protection against AD, whereas there is some evidence for the role of dietary changes in alleviating AD and airway inflammation. More randomized controlled trials are needed to clarify the potential of epicutaneous immunotherapy as a therapeutic strategy for patients with FA. Summary The growing understanding of the gut-skin interactions on allergic disease pathogenesis presents novel avenues for therapeutic interventions which target modulation of the gut and/or skin. |
| تدمد: | 1531-7056 0267-1379 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::77f7eb5237226a3ef8bfc2ee47c7dafe https://doi.org/10.1097/mog.0000000000000780 |
| رقم الأكسشن: | edsair.doi...........77f7eb5237226a3ef8bfc2ee47c7dafe |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15317056 02671379 |
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