Serial measurement of global longitudinal strain among women with breast cancer treated with proton radiation therapy
| العنوان: | Serial measurement of global longitudinal strain among women with breast cancer treated with proton radiation therapy |
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| المؤلفون: | M Hassan, M Awadalla, T C Tan, M Scherrer-Crosbie, L Zhang, D A Zlotoff, R Bany Bakar, S B Hickey, S A Patel, J L Januzzi, J J Passeri, F Keane, R Jimenez, S M MacDonald, T G Neilan |
| المصدر: | European Heart Journal. 42 |
| بيانات النشر: | Oxford University Press (OUP), 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Cardiology and Cardiovascular Medicine |
| الوصف: | Background Conventional photon radiotherapy (RT) for breast cancer is associated with reduction in global longitudinal strain (GLS), an increase in both troponin and N-terminal pro-B type natriuretic peptide (NT-proBNP), and incident heart failure. The cardiac radiation exposure with proton-RT is reduced and, thus may be associated with less cardiotoxicity. Objectives To test the effect of proton-RT on GLS, troponin and NT-proBNP. Methods A prospective observational single center study of 69 women being treated with proton-RT for breast cancer. Serial measurements of GLS, high-sensitivity cardiac troponin-I (hs-cTnI), and NT-proBNP were performed at pre-specified intervals (pre proton-RT, 4 weeks after completion of proton-RT and again at 2 months post proton-RT). Results The mean age was 46±11 years, BMI was 25.6±5.2 kg/m2, 32% had hypertension and mean radiation dose to the heart and left ventricle (LV) were 0.44 Gy and 0.12 Gy respectively. There was no change in LV ejection fraction (pre proton-RT vs. 4-weeks post proton-RT vs. 2 months post proton-RT, 65±5 vs. 66±5 vs. 64±4%, p=0.15), global GLS (−21.7±2.7 vs. −22.7±2.3 vs. −22.8±2.1%, p=0.24) or segmental GLS from pre-to post proton-RT. Similarly, there was no change in hs-cTnI or NT-proBNP with proton-RT. However, post proton-RT, we found that patients with a history of hypertension had lower GLS when compared to women without hypertension (−21.3±3.5 vs. −24.0±2.4%, p=0.006). Conclusion Proton-RT did not impact LV function, or associate with an increase in biomarkers. These data support the potential cardiac benefits of proton-RT compared to conventional RT. Funding Acknowledgement Type of funding sources: None. |
| تدمد: | 1522-9645 0195-668X |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::798d1e23292307c814953dcc68177606 https://doi.org/10.1093/eurheartj/ehab724.2850 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi...........798d1e23292307c814953dcc68177606 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15229645 0195668X |
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