Antioxidant and Cytoprotective Effects of New Diarylheptanoids from Rhynchanthus beesianus
| العنوان: | Antioxidant and Cytoprotective Effects of New Diarylheptanoids from Rhynchanthus beesianus |
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| المؤلفون: | Xing-Wei Yang, Pei-Feng Zhu, Lan-Qin Zhao, Afsar Khan, Li Mengcheng, Gui-Guang Cheng, Xiao-Dong Luo, Bu-Yun Zhang, Ya-Ping Liu |
| المصدر: | Journal of Agricultural and Food Chemistry. 69:6229-6239 |
| بيانات النشر: | American Chemical Society (ACS), 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 0106 biological sciences, Natural product, ABTS, Antioxidant, biology, Phenylpropanoid, DPPH, medicine.medical_treatment, 010401 analytical chemistry, Diarylheptanoid, General Chemistry, biology.organism_classification, 01 natural sciences, 0104 chemical sciences, chemistry.chemical_compound, chemistry, Biochemistry, medicine, Zingiberaceae, General Agricultural and Biological Sciences, Diarylheptanoids, 010606 plant biology & botany |
| الوصف: | Rhynchanthus beesianus (Zingiberaceae) has been an important food spice and vegetable in southern China. Fifteen phenolic compounds (1-15) including three new diarylheptanoids, rhynchanines A-C (1-3) and one new phenylpropanoid, 4-O-methylstroside B (9), were isolated from R. beesianus rhizomes. The structures of new compounds were elucidated by comprehensive analyses through NMR, HRMS technique, acid hydrolysis, and Mosher's reaction. Among them, compound 5 is the first isolated natural product and its NMR data are reported. Most of the isolated compounds, especially 3-6 and 8, showed significant antioxidant activities on DPPH, ABTS+ radical scavenging, and FRAP assays. Furthermore, the antioxidant phenolic compounds were evaluated for their cytoprotective capacity against H2O2-induced oxidative stress in HepG-2 cells. Compounds 3 and 5 could significantly inhibit reactive oxygen species production, and compounds 3, 5, and 6 could remarkably prevent the cell apoptosis. Then, the R. beesianus rhizome, which contained phenolic compounds, might serve as a functional food for potential application on preventing oxidative stress-connected diseases. |
| تدمد: | 1520-5118 0021-8561 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::79dab7a9d599a801c2418c2bbd118648 https://doi.org/10.1021/acs.jafc.1c00869 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi...........79dab7a9d599a801c2418c2bbd118648 |
| قاعدة البيانات: | OpenAIRE |
Find this issue from the American Chemical Society | تدمد: | 15205118 00218561 |
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