Autoantikörper gegen exokrines Pankreas und gegen intestinale Becherzellen in der Diagnostik des Morbus Crohn und der Colitis ulcerosa*
| العنوان: | Autoantikörper gegen exokrines Pankreas und gegen intestinale Becherzellen in der Diagnostik des Morbus Crohn und der Colitis ulcerosa* |
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| المؤلفون: | W. Stöcker, D. Normann, K Stöcker, G. Jantschek, M. Otte, S. Ulrich |
| المصدر: | DMW - Deutsche Medizinische Wochenschrift. 109:1963-1969 |
| بيانات النشر: | Georg Thieme Verlag KG, 2008. |
| سنة النشر: | 2008 |
| مصطلحات موضوعية: | Immunoglobulin A, medicine.medical_specialty, Crohn's disease, biology, business.industry, General Medicine, medicine.disease, Ulcerative colitis, Gastroenterology, digestive system diseases, Serology, Intestinal mucosa, Sulfasalazine, Internal medicine, medicine, biology.protein, Pancreatitis, Colitis, business, medicine.drug |
| الوصف: | It was demonstrated by indirect immunofluorescence that Crohn's disease and ulcerative colitis are serologically distinct. In 59 patients with Crohn's disease, confirmed by endoscopy and histology, 23 (39%) had serum autoantibodies against exocrine pancreas; in 17 (29%) the titre was 1 : 100 or higher. In 46 patients with confirmed ulcerative colitis pancreas antibodies were demonstrated only twice, in 100 healthy control subjects only 3 times, with titres less than 1 : 100. Pancreas antibodies do not occur in high concentrations in pancreatitis; titres higher than 1 : 100 therefore suggest Crohn's disease. The pancreas antibodies of patients with Crohn's disease were predominantly immunoglobulins IgA and IgG, twice they were IgD and once IgM, never IgE. In 6 patients the pancreas antibodies fixed complement. Autoantibodies against intestinal goblet cells were found only in patients with ulcerative colitis (13 of 46 = 28%). The titres range was from 1 : 10 to 1 : 1000. The goblet-cell antibodies consisted only of IgA and IgG, never reacting with complement. These results indicate that determining pancreas and goblet-cell antibodies alone will make it possible to diagnose either Crohn's disease or ulcerative colitis in more than a quarter of patients with chronic inflammatory intestinal disease. |
| تدمد: | 1439-4413 0012-0472 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::7a4ea4ac98ef218ae85af8bd30199d44 https://doi.org/10.1055/s-2008-1069485 |
| رقم الأكسشن: | edsair.doi...........7a4ea4ac98ef218ae85af8bd30199d44 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14394413 00120472 |
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