Considerable advancement in the area of biomedical research and biotechnology has attributed a new shape to the lifestyle and healthcare. However, emerging and re-emerging infectious diseases have always been a major threat coupled with immense challenges, suggesting the necessity of implication of innovative approaches and advanced technologies. Contaminated water is the predominant cause of human exposure to the infectious etiological agents including pathogens, toxins, and organic and inorganic contaminants. Water safety plans (WSP) have been included in the WHO guidelines for drinking-water quality with several imperative primary objectives.