Effect of tianeptine on neuroendocrine, enzyme and behavioral responses to restraint stress in male rats
| العنوان: | Effect of tianeptine on neuroendocrine, enzyme and behavioral responses to restraint stress in male rats |
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| المؤلفون: | X. De Grieve, J. Picard, J. Mimouni, M. Pugeat, C. Bange, R. Fontanges |
| المصدر: | European Psychiatry. 8:67s-73s |
| بيانات النشر: | Cambridge University Press (CUP), 1993. |
| سنة النشر: | 1993 |
| مصطلحات موضوعية: | medicine.medical_specialty, Chemistry, Neuroendocrinology, 030227 psychiatry, 03 medical and health sciences, Psychiatry and Mental health, 0302 clinical medicine, Endocrinology, Internal medicine, Male rats, medicine, Tianeptine, Restraint stress, 030217 neurology & neurosurgery, Depression (differential diagnoses), medicine.drug |
| الوصف: | SummaryThe effects of the novel antidepressant tianeptine, after acute or chronic administration, were compared in normal and restraint-stressed (30 min or 2 h) Wistar rats. Tianeptine, at the dose of 10 mg/kg, did not exert any effect in non-stressed rats. However, in animals restrained for 30 min, tianeptine reduced the increase of circulating ACTH and β-endorphin levels without modification of corticosterone. Moreover, it antagonized the deficit of vertical exploratory activity in an open field. In rats restrained for 2 hours, a single injection of tianeptine suppressed the stress-induced increase of TAT hepatic activity and moderately attenuated the deficit of activity in the open field. This effect was less marked and not statistically significant after chronic treatment. |
| تدمد: | 1778-3585 0924-9338 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::7c0fa84a210c4b218b0153d05596095f https://doi.org/10.1017/s0924933800005411 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi...........7c0fa84a210c4b218b0153d05596095f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17783585 09249338 |
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