Psoriasis is an immune-mediated, multicausal skin, and joint affliction especially characterized by keratinocyte hyperproliferation and abnormal differentiation, resulting in inflamed, scaly red raised plaques. This pathology is currently incurable, although there is a spectrum of local and systemic therapeutic options, which can restore a symptomless or visibly healthy skin. Thereby, to better understand the etiology and pathogenesis of psoriasis, many pathological models have been developed. Among them, in vitro models represent suitable alternatives to in vivo models for numerous technical, practical, and ethical reasons. They are produced using various techniques, from which emerge their own peculiarities, but of course share a common endeavor: to overcome the lack of validated models or naturally occurring specimens, which fully mirror both the psoriasis phenotype and immunopathogenesis. Key objectives of this chapter include introducing the pathology and the multidisciplinary field of tissue engineering and presenting the psoriatic in vitro models that have been developed.
