Tunable Anticancer Activity of Furoylthiourea‐Based Ru II –Arene Complexes and Their Mechanism of Action
| العنوان: | Tunable Anticancer Activity of Furoylthiourea‐Based Ru II –Arene Complexes and Their Mechanism of Action |
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| المؤلفون: | Maroli Nikhil, Ponmalai Kolandaivel, Krishna Kadirvelu, Naveen Kumar Kalagatur, Jebiti Haribabu, Nattamai Bhuvanesh, Ramasamy Karvembu, Nithya Balakrishnan, Srividya Swaminathan |
| المصدر: | Chemistry – A European Journal. 27:7418-7433 |
| بيانات النشر: | Wiley, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Aqueous solution, 010405 organic chemistry, Ligand, Stereochemistry, Organic Chemistry, Substituent, Biological activity, General Chemistry, 010402 general chemistry, 01 natural sciences, Catalysis, 0104 chemical sciences, chemistry.chemical_compound, Mechanism of action, chemistry, Cancer cell, medicine, Electronic effect, medicine.symptom, Receptor |
| الوصف: | Fourteen new RuII -arene (p-cymene/benzene) complexes (C1-C14) have been synthesized by varying the N-terminal substituent in the furoylthiourea ligand and satisfactorily characterized by using analytical and spectroscopic techniques. Electrostatic potential maps predicted that the electronic effect of the substituents was mostly localized, with some influence seen on the labile chloride ligands. The structure-activity relationships of the Ru-p-cymene and Ru-benzene complexes showed opposite trends. All the complexes were found to be highly toxic towards IMR-32 cancer cells, with C5 (Ru-p-cymene complex containing C6 H2 (CH3 )3 as N-terminal substituent) and C13 (Ru-benzene complex containing C6 H4 (CF3 ) as N-terminal substituent) showing the highest activity among each set of complexes, and hence they were chosen for further study. These complexes showed different behavior in aqueous solutions, and were also found to catalytically oxidize glutathione. They also promoted cell death by apoptosis and cell cycle arrest. Furthermore, the complexes showed good binding ability with the receptors Pim-1 kinase and vascular endothelial growth factor receptor 2, commonly overexpressed in cancer cells. |
| تدمد: | 1521-3765 0947-6539 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::7d081de0eaa42f3cf7bb39bd90badd0c https://doi.org/10.1002/chem.202004954 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi...........7d081de0eaa42f3cf7bb39bd90badd0c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15213765 09476539 |
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