التفاصيل البيبلوغرافية
| العنوان: |
Hindbrain regional growth in preterm newborns and its impairment in relation to brain injury |
| المؤلفون: |
Xiaoyue M. Guo, Dawn Gano, Christopher P. Hess, Alisa Unzueta, Mai-Lan Ho, Duan Xu, Donna M. Ferriero, A. James Barkovich, Hosung Kim |
| المصدر: |
Human Brain Mapping. 37:678-688 |
| بيانات النشر: |
Wiley, 2015. |
| سنة النشر: |
2015 |
| مصطلحات موضوعية: |
Cerebellum, Radiological and Ultrasound Technology, Neurogenesis, Physiology, Hindbrain, medicine.disease, Pons, Cerebral Intraventricular Hemorrhage, 03 medical and health sciences, 0302 clinical medicine, medicine.anatomical_structure, Neurology, Premature birth, 030225 pediatrics, Severity of illness, medicine, Radiology, Nuclear Medicine and imaging, Neurology (clinical), Brainstem, Anatomy, Psychology, Neuroscience, 030217 neurology & neurosurgery |
| الوصف: |
Premature birth globally affects about 11.1% of all newborns and is a risk factor for neurodevelopmental disability in surviving infants. Histology has suggested that hindbrain subdivisions grow differentially, especially in the third trimester. Prematurity-related brain injuries occurring in this period may selectively affect more rapidly developing areas of hindbrain, thus accompanying region-specific impairments in growth and ultimately neurodevelopmental deficits. The current study aimed to quantify regional growth of the cerebellum and the brainstem in preterm neonates (n = 65 with individually multiple scans). We probed associations of the regional volumes with severity of brain injury. In neonates with no imaging evidence of injury, our analysis using a mixed-effect linear model showed faster growth in the pons and the lateral convexity of anterior/posterior cerebellar lobes. Different patterns of growth impairment were found in relation to early cerebral intraventricular hemorrhage and cerebellar hemorrhage (P < 0.05), likely explaining different mechanisms through which neurogenesis is disrupted. The pattern of cerebellar growth identified in our study agreed excellently with details of cerebellar morphogenesis in perinatal development, which has only been observed in histological data. Our proposed analytic framework may provide predictive imaging biomarkers for neurodevelopmental outcome, enabling early identification and treatment of high-risk patients. Hum Brain Mapp 37:678-688, 2016. © 2015 Wiley Periodicals, Inc. |
| تدمد: |
1065-9471 |
| URL الوصول: |
https://explore.openaire.eu/search/publication?articleId=doi_________::7e8352042958d1ba328d79b4c3500210
https://doi.org/10.1002/hbm.23058 |
| حقوق: |
OPEN |
| رقم الأكسشن: |
edsair.doi...........7e8352042958d1ba328d79b4c3500210 |
| قاعدة البيانات: |
OpenAIRE |
