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HPLC Analysis and Pharmacokinetics of Picroside I in Dog Plasma

التفاصيل البيبلوغرافية
العنوان: HPLC Analysis and Pharmacokinetics of Picroside I in Dog Plasma
المؤلفون: Jing Lv, Xiaodan Zhao, Yunhua Ye, Yawei Zhou, Huina Wang, Liyi Pan
المصدر: Chromatographia. 66:261-265
بيانات النشر: Springer Science and Business Media LLC, 2007.
سنة النشر: 2007
مصطلحات موضوعية: Hplc analysis, Chromatography, Chemistry, Organic Chemistry, Clinical Biochemistry, Central compartment, Biochemistry, High-performance liquid chromatography, Picroside I, Lower limit, Analytical Chemistry, Pharmacokinetics, Blood plasma, Quantitative analysis (chemistry)
الوصف: A sensitive and selective HPLC–UV method established for determination of picroside I in dog plasma has been used to study the pharmacokinetics of the drug after intravenous administration of three different doses. Sample pretreatment consists in deproteination by addition of acetonitrile; l-ascorbic acid was used to improve the stability of picroside I. The lower limit of quantification of picroside I was 0.05 μg mL−1. The recovery of the method was up to 90%. After intravenous administration to dogs picroside I was mainly distributed in the central compartment and was rapidly eliminated from the plasma; the mean elimination half-life was 30.54 ± 4.34, 30.20 ± 3.78, and 34.02 ± 1.88 min for doses of 2.5, 5, and 15 mg kg−1, respectively, and the respective values of AUC 0–∞ were 81.04 ± 19.95, 198.50 ± 27.77, and 586.44 ± 103.08 μg min mL−1. The different doses had no significant effect on the main pharmacokinetic data and the kinetics seemed to be linear in dosage range 2.5–15 mg kg−1.
تدمد: 1612-1112
0009-5893
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::7f63fd955112a13c7fa0d3fad8106360
https://doi.org/10.1365/s10337-007-0288-5
رقم الأكسشن: edsair.doi...........7f63fd955112a13c7fa0d3fad8106360
قاعدة البيانات: OpenAIRE
الوصف
تدمد:16121112
00095893